[Population morbidity in Sofia as a reflection of the territorial characteristics of air pollution in the city]. / Zaboliaemostta na naselenieto v Sofiia kato otrazhenie na teritorialnite osobenosti na atmosfernoto zamursiavane v grada.

A study of ambient air pollution differences over the residential areas in Sofia and the effect of the morbidity of the population has been carried out. Correlation analysis between the average concentrations of particulates, SO2, NO2, H2S, phenol and lead, and the incidence of several groups of diseases among adults and children has been performed. It has been found out that air pollution is more intensive in the centre of the city as a consequence of the heavy motor vehicle traffic and the old way of town planning. The results point out also that diseases of the lung, eye and skin are more frequent among the residents of city areas situated next to industrial zones, while diseases of the cardiovascular, hemopoietic and endocrine systems are more typical in the city centre as compared to a control residential areas. Although ambient air pollution has been found to the moderate, the correlation analysis suggests an influence of air pollution on the incidence of chronic diseases and immune imbalance. It is supposed that each pollutant possesses an individual risk potential.

[Experimental research on the effect of bioshik (tinidazole) on reproduction indices]. / Eksperimentalni prouchvaniia na vliianieto na bioshik (tinidazol) vurkhu niakoi pokazateli za reproduktivnost.

Studies were carried out on the influence of bioshik (tinidazol), synthesised and produced by NPSK of Pharmacy at the Medical Academy on reproduction of male and female rats. The experiments were undertaken after oral administration of bioshik in two doses of 100 mg and 300 mg/kg of body mass (1/20 and 1/10 of LD50) at several stages: I stage during natal application, respectively: 1. during sexual maturation and 2. during the period of sexual maturity and II stage during prenatal administration of bioshik. The studies of the second stage were performed on 3-months old male and female rats, a generation of animals, treated with bioshik during pregnancy. The following parameters were determined: sexual receptivity, reproduction, percentage of early resorptions and mean number of normally implanted fetuses. The described data showed that there was inhibition of sexual receptivity as well as of reproduction after usage of higher doses of 300 mg/kg of body mass only natally and more manifested after application during sexual maturation. There were no data on impairement of the examined parameters for reproduction in offsprings after treatment of pregnant rats with bioshik.

[The role of the serotoninergic system of the brain in cimetidine-stimulated prolactin secretion]. / Prouchvaniia vurkhu na serotoninergichnata sistema na mozuka pri tsimetidinstimuliranata sekretsiia na prolaktin.

Pharmacological studied were made on serotoninergic drugs (5-hydroxytryptophane, metisergid and p-chlorphenylalanin) to clarify mechanisms of cymetidine-stimulating secretion of prolactin. The experiments were carried out on white male rats at two stages: the first stage, in which dose-dependent influence of cymetidine on the release of prolactin was determined; and second stage, in which studies with indicated serotoninergic drugs after their 5-day administration were made on prolactin content after treatment with cymetidine in two doses of 20 mg/kg and 80 mg/kg of body mass. Prolactin content was determined in sera of male rats by a radioimmunological method. The results showed the influence of drugs--agonists and antagonists of serotonine on the release of prolactin after cymetid action and gave foundation to discuss them as a possible serotoninergic mechanism after cymetidine-stimulating secretion of prolactin. The results indicate the possibilities for clinical trial of serotoninergic drugs as correction of the side effect of cymetidine on prolactin secretion.

[The effect of dopaminergic pharmacological agents on the pancreatic islet apparatus in rats]. / Vliianie na dopaminergichni farmakologichni sredstva vurkhu insularniia aparat na pankreasa na plukhove.

Experimental studies were carried out on white male sexual mature healthy rats with induced alloxan diabetes, to clarify the role of dopaminergic system in the regulation of functions of the insular apparatus of the pancreas. The experiments were performed by the following drugs: bromrcripine, levodopa, a combination of revodopa plus carbidopa and haloperidol. Parameters of carbohydrate metabolism were determined in the course of acute and chronic experiments. The results sustained the hypothesis for participation of dopaminergic system in the regulation of production and secretion of insulin and respectively in the control of carbohydrate metabolism. Independent studies were carried out on white rats with alloxan diabetes after combined administration of dopaminergic pharmacological drugs and sulphanylureic preparation (SUP)-glybenclimide. The mechanisms of interaction after the combined administration of the investigated drugs under the conditions of experimental diabetes mellitus were clarified. The obtained results supplement data, in support of the hypothesis for the role of dopamine as a neuromediator in the regulation of the insular apparatus of the pancreas.