[Change in indicators of metabolism and kidney function in intact rats after parenteral administration of sodium hypochlorite]. / Izmenenie pokazatelei metabolizma i funktii pochek u intaktnykh krys posle parenteral'nogo vvedeniia gipokhlorita natriia.

The changes of kidney metabolism, function and enzymuria activity of nephron epithelium cells after 4 days of parenteral administration of sodium hypochlorite 0.02% and 0.06% solutions were investigated in the experiments on 15 intact non-inbred rats of 200-280 g body weight. It was revealed that sodium hypochlorite induced metabolic damage to the kidney similar to ischemic one. The 0.02 and 0.06% solutions of sodium hypochlorite administered parenterally produced no negative effect on renal function. There was no significant rise of enzymuria activity in experimental groups compared to the controls. Moreover, enzymuria of four from six nephron epithelium cell enzymes decreased significantly to day 5 of the experiment. Metabolic damage and enzymuria activity changes were more pronounced in rats given parenteral 0.06% solution of sodium hypochlorite.

[Increase in structural-functional tolerance of kidney to ischemia upon parenteral administration of sodium hypochlorite in the pre-ischemic period]. / Povyshenie strukturo-funktsional'noi tolerantnosti pochek k ishemii pri parenteral'nom vvedenii gipokhlorita natriia v predyshemicheskom periode.

The opportunity of raising kidney structural and functional tolerance to ischemia with parenteral injections of 0.06% solution of sodium hypochlorite for 4 days in preischemia period was studied in experiment on 22 non-inbred rats of 200-280 g body weight. 90 minute ischemia was created by ligating the left and right kidney arteries, veins, ureters. Morphological and functional kidney data, enzymuria activity of nephron epithelium cells were registered, 80 and 33% of the rats survived 7 days after ischemia in the study and control groups, respectively. The control animals showed deterioration of the tubules function, high enzymuria. Thus, it is possible to raise kidney tolerance to ischemia by preischemic parenteral injection of sodium hypochlorite solution.

[Sodium hypochlorite in the treatment of bacteremic circulatory shock]. / Gipokhlorit natriia v lechenii infektsionno-toksicheskogo sosudistogo shoka.

17 patients with massive urinary infection and bacteriemic circulatory shock received a combined intensive treatment including indirect electrochemical blood oxidation (IEBO) with 0.06% solution of sodium hypochlorite (SHC). SHC intravenous infusions resulted in stabilization of arterial pressure within 24 hours. IEBO in the treatment of incipient bacteriemic shock improves prognosis.

[The conditions for performing extracorporeal lithotripsy with different physicochemical compositions of the urinary stones]. / Usloviia provedeniia distantsionnoi litotripsii pri razlichnom fiziko-khimicheskom sostave mochevykh kamnei.

Remote impulse lithotripsy (RIL) parameters were assessed when crushing uroliths with the use of URAT-II lithotriptor. The results were referred to the concrement size, location and physicochemical properties. A total of 365 examinations were made. Disintegration of large concrements, including coral calculi occurred in response to less number of impulses than it was necessary for destruction of concrements up to 1.5 cm in size. The hardest were vitlokite and cystine stones. The lowest traumaticity was observed in disintegration of the concrements composed of struvite and carbonatapatite.

[Status of water-electrolyte homeostasis and the systems of hormonal regulation during 237-day space flight]. / Sostoianie vodno-solevogo gomeostaza i sistem gormonal'noi reguliatsii pri 237-sutochnom kosmicheskom polete.

On mission days 216-219 two crewmembers collected urine and recorded their food and water consumption during three days on end. The cosmonaut-physician withdrew blood samples from the vein and finger. In addition, he made venipuncture to himself and drew blood. Urine and blood samples were frozen and returned to the ground for analysis. In spite of individual variations of each cosmonaut, they all showed a trend for water and sodium retention which was provided by adequate hormonal rearrangement, i. e. increased production of ADH and aldosterone. No disorders in calcium and phosphorus metabolism were seen. Immediately postflight the cosmonauts displayed typical changes in fluid-electrolyte balance and renal function that suggested body dehydration and adjustment to Earth's gravity.

[The use of the enterosorbent polifepan in the combined treatment of patients with dermatoses]. / Primenenie énterosorbenta polifepana v kompleksnom lechenii bol'nykh nekotorymi dermatozami.

Polyfepan, an enterosorbent, was used in the treatment of 96 dermatologic patients. The treatment proved to be effective in those with toxicoderma, secondary xanthomatosis, porphyria cutanea tarda, skin itching, and urticaria, particularly in the cases when toxic exposures and gastrointestinal conditions contributed to the disease pathogenesis. Polyfepan enterosorption is harmless, well-tolerated, and simple.

[Use of polyfepan in the treatment of suppurative wounds]. / Primenenie polifepana pri lechenii gnoinykh ran.

An analysis of application of medical lignin (polyfepan) in treatment of purulent wounds of different etiology in 60 patients is presented. Good clinical effects of polyfepan in treatment of purulent wounds allow putting secondary sutures or approximating the wound margins at earlier terms. It gives no complications, is well endurable by the patients and easy in use. All these qualities allow polyfepan to be recommended for the local treatment of purulent wounds as a sorbent.