An Unsupervised Classifier for Whole-Genome Phylogenies, the Maxwell© Tool.

The development of phylogenetic trees based on RNA or DNA sequences generally requires a precise and limited choice of important RNAs, e.g., messenger RNAs of essential proteins or ribosomal RNAs (like 16S), but rarely complete genomes, making it possible to explain evolution and speciation. In this article, we propose revisiting a classic phylogeny of archaea from only the information on the succession of nucleotides of their entire genome. For this purpose, we use a new tool, the unsupervised classifier Maxwell, whose principle lies in the Burrows-Wheeler compression transform, and we show its efficiency in clustering whole archaeal genomes.

Maxwell®: An Unsupervised Learning Approach for 5P Medicine.

In the 5P medicine (Personalized, Preventive, Participative, Predictive and Pluri-expert), the general trend is to process data by displacing the barycenter of the information from hospital centered systems to the patient centered ones through his personal medical records. Today, the use of artificial intelligence for supporting this transition shows real limitations in its implementation in operational practice, both at the level of patient care, but also in the general daily life of the health professional, because of the medico-legal imperatives induced by the promises of the '5P medicine'. In this paper, we propose to fill this gap by introducing an original artificial intelligence platform, named Maxwell, which follows an unsupervised learning approach in line with the medico-legal imperatives of the '5P medicine'. We describe the functional platform characteristics and illustrate them by two examples of clustering in genomics and magnetic resonance imaging.