Hematopoietic Stem Cell Transplantation in Egypt: Challenges and Opportunities.

Hematopoietic stem cell transplantation (HSCT) is now an established treatment modality with definitive indications for many hematological disorders. However, HSCT requires tremendous resources, and it is increasingly challenging for transplantation experts to practice in the developing world and to reach a compromise between requirements and available resources. Based on 30 years of experience and 4256 transplants (60% allogeneic and 40% autologous), this article focuses on the challenges our HSCT program encountered since it started in 1989 and what opportunities we see to solve them. Since 1997, HSCT procedures increased dramatically with the opening of 15 HSCT units distributed all over Egypt.

Environmental exposure to asbestos and the exposure-response relationship with mesothelioma.

An epidemiological and environmental study was carried out in Shubra El-Kheima city, greater Cairo, of the exposure-response relationship between asbestos and malignant pleural mesothelioma. Radiological screening was done for 487 people occupationally exposed to asbestos, 2913 environmentally exposed to asbestos and a control group of 979 with no history of exposure. Pleural biopsy was done for suspicious cases. The airborne asbestos fibre concentrations were determined in all areas. There were 88 cases of mesothelioma diagnosed, 87 in the exposed group. The risk of mesothelioma was higher in the environmentally exposed group than other groups, and higher in females than males. The prevalence of mesothelioma increased with increased cumulative exposure to asbestos.

Environmental exposure to asbestos and the exposure-response relationship with mesothelioma

An epidemiological and environmental study was carried out in Shubra El-Kheima city, greater Cairo, of the exposure-response relationship between asbestos and malignant pleural mesothelioma. Radiological screening was done for 487 people occupationally exposed to asbestos, 2913 environmentally exposed to asbestos and a control group of 979 with no history of exposure. Pleural biopsy was done for suspicious cases. The airborne asbestos fibre concentrations were determined in all areas. There were 88 cases of mesothelioma diagnosed, 87 in the exposed group. The risk of mesothelioma was higher in the environmentally exposed group than other groups, and higher in females than males. The prevalence of mesothelioma increased with increased cumulative exposure to asbestos

Ventriculo-Peritoneal Shunt Infections in Infants and Children

Objective: To determine the rate and the type of ventriculoperitoneal (VP) shunt infections in infants and children admitted to King Fahad Hofuf hospital of Al-Ahsaa area at the Eastern Province of Saudi Arabia. Methods: From mid 2003 to end of 2006; VP shunt infection episodes were reviewed. Once infection was suspected; a cerebro- spinal fluid (CSF) sample was taken and empirical antibiotics were recommended. Once infection was confirmed; VP shunt was removed and external ventricular drainage (EVD) was inserted until CSF became sterile after which a new shunt was inserted. Results : 25.9 of patients with VP shunts had infections which represents 29.3of the procedures. 40 of infected patients had recurrent episodes. 59.1 of infections occurred throughout the first two months following insertion. Single pathogen was isolated in each episode. Pseudomonas auerginosa represented 50 of isolated pathogens compared with 18.2 with Staphylococcus epidermidis. Conclusions There is a high incidence of VP shunt infections in King Fahad Hofuf hospital when compared with other international centres. Gram negative organisms are the most common cause of the infection

Traumatic Brain Injury in Pediatric Age Group: Predictors of Outcome in Pediatric Intensive Care Unit

Objective: To determine predictors for outcomes of traumatic brain injury (TBI) in infants and children younger than twelve years admitted to our pediatric intensive care units (PICU).Methods: This is a retrospective cohort study from 2004-5; done at the PICU of King Fahad Hofuf Hospital; Eastern Province; Saudi Arabia. One hundred and six patients with TBI; 65 boys and 41 girls ages 12 or under; with a mean age of 5.7 years; were included. Of them; 11.3died (Deaths group); 11survived with neurological deficits (ND-group); and 77survived with no neurological deficits (NND-group). The potential predictors for death or neurological deficits were examined.Results: 83of deaths had initial Glascow coma scale (GCS) of = 4/15; 50of ND had initial GCS = 8 and 27of NND had GCS 12. The initial brain CT was abnormal in 92of deaths and ND groups; but in only 37of NND. Combined brain pathologies were found in 92of deaths; 63of ND and only in 5of NND. Hypotension was seen in 67of deaths; 17ND and only in 1of NND. Mechanical ventilation was required in all deaths and more than half of ND. Liver enzymes were high in 50of deaths and 66of ND but in only 20of NND. Serum albumin was low in 33of deaths; 42of ND and only 1NND.Conclusion: Glasgow coma score; brain CT findings; combined brain pathologies; hypotension; high liver enzymes and low serum albumin predict outcome after TBI in pediatric age group