Eficacia del bupropión en el tratamiento de la dependencia de pemolina / Efficacy of bupropion in the treatment of pemoline dependence

Presentamos el caso de una mujer que solicita evaluación psiquiátrica por llevar 6 meses consumiendo pemolina en unas dosis de entre 100 y 150 mg/día, encontrándose con dificultades para abandonar el consumo de dicha sustancia. La instauración de 300 mg/día de bupropión resuelve la dependencia que tenía la enferma. Proponemos el uso de antidepresivos como el bupropión para el tratamiento de conductas adictivas sobre estimulantes del sistema nervioso central

We present the case of a woman who requested psychiatric evaluation because she had been taking pemoline for six months at a dose between 100-150 mg/day, and was finding it difficult to discontinue taking this substance. Initiation of 300 mg/day of bupropion solved the patient's dependence problem. We propose using antidepressants such as bupropion for the treatment of addictive behaviors due to central nervous system stimulants

Efficacy of bupropion in the treatment of pemoline dependence.

We present the case of a woman who requested psychiatric evaluation because she had been taking pemoline for six months at a dose between 100-150 mg/day, and was finding it difficult to discontinue taking this substance. Initiation of 300 mg/day of bupropion solved the patient's dependence problem. We propose using antidepressants such as bupropion for the treatment of addictive behaviors due to central nervous system stimulants.

Antecedentes de abusos sexuales en pacientes con bulimia nerviosa: su influencia en el estado clínico / History of sexual abuse in patients with bulimia nervosa: its influence on clinical status

Introducción. Los estudios que han analizado la relación entre abusos sexuales y bulimia nerviosa (BN) han arrojado resultados discordantes. El objetivo del presente estudio fue valorar la influencia de los antecedentes de abuso sexual en el estado clínico de un grupo de pacientes diagnosticados de BN con criterios DSM-IV. Métodos. Fueron evaluados 70 pacientes con BN usando instrumentos clínicos específicos: el Test de Actitudes Alimentarias–40 ítems (EAT-40), el Test de Investigación de Bulimia Edimburgo (BITE), el Listado de Comprobación de Síntomas (SCL-90), la Entrevista Clínica Estructurada para los Trastornos del Eje II del DSM-IV (SCID-II), el Test de 16 Factores de Personalidad (16-PF) y una entrevista clínica para la valoración del uso pasado y actual de sustancias. Los datos de los 15 pacientes con una historia previa de abusos sexuales (21,4 % de la muestra) fueron comparados con los de los 55 pacientes sin tales antecedentes. Resultados. Ambos grupos fueron muy similares con respecto a la intensidad de los síntomas. Sólo la tendencia a la somatización y puntuaciones más altas en el factor E del 16-PF (dominancia) aparecieron asociados a los antecedentes de abusos sexuales en la muestra. Conclusiones. Los resultados apoyan la idea de que los abusos sexuales pueden asociarse a una mayor vulnerabilidad no específica para presentar trastornos psicopatológicos, pero no aumentan la intensidad de la psicopatología en los pacientes con BN

Introduction.Studies analyzing the relationship between sexual abuse and bulimia nervosa (BN) have reported discrepant results. This study aimed to assess the role of a history of sexual abuse in the clinical status of a group of patients diagnosed of BN using DSM-IV diagnostic criteria. Methods. Seventy patients with BN were assessed using specific clinical tools: Eating Attitudes Test-40 items (EAT-40), Bulimia Investigation Test Edinburgh (BITE), Symptom Checklist (SCL-90), Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II), Sixteen Personality Factors Test (16-PF) and a clinical interview for the assessment of past and current substance abuse. The data from the 15 patients with a history of sexual abuse (21.4 % of the sample) were compared with those from the 55 patients without such a history. Results. Both groups were very similar regarding symptom severity. Only the tendency to somatization and higher scores in the factor E of the 16-PF (dominance) were associated with antecedents of sexual abuse in the sample. Conclusions. The results support the idea that sexual abuse may be related to higher non-specific vulnerability to psychopathology, but do not increase symptom severity in BN patients

[History of sexual abuse in patients with bulimia nervosa: its influence on clinical status]. / Antecedentes de abusos sexuales en pacientes con bulimia nerviosa: su influencia en el estado clínico.

INTRODUCTION: Studies analyzing the relationship between sexual abuse and bulimia nervosa (BN) have reported discrepant results. This study aimed to assess the role of a history of sexual abuse in the clinical status of a group of patients diagnosed of BN using DSM-IV diagnostic criteria. METHODS: Seventy patients with BN were assessed using specific clinical tools: Eating Attitudes Test-40 items (EAT-40), Bulimia Investigation Test Edinburgh (BITE), Symptom Checklist (SCL-90), Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II), Sixteen Personality Factors Test (16-PF) and a clinical interview for the assessment of past and current substance abuse. The data from the 15 patients with a history of sexual abuse (21.4 % of the sample) were compared with those from the 55 patients without such a history. RESULTS: Both groups were very similar regarding symptom severity. Only the tendency to somatization and higher scores in the factor E of the 16-PF (dominance) were associated with antecedents of sexual abuse in the sample. CONCLUSIONS: The results support the idea that sexual abuse may be related to higher non-specific vulnerability to psychopathology, but do not increase symptom severity in BN patients.