[Use of phospholipids to repair rat liver membranes during carbon tetrachloride poisoning]. / Reparatsiia fosfolipidami membran pecheni krys pri otravlenii tetrakhlormetanom.

The effect of phospholipid multilayer liposomes on the properties of endoplasmic reticular membranes has been studied in hepatic cells damaged with CCl4. It has been shown that the repair effect of phosphatidylcholine liposomes was manifested in vivo by normalization of phospholipid membrane composition, reduction in the degree of cytochrome P-450 inactivation, partial normalization of its hydroxylase activity and recovery of glucose-6-phosphatase activity. The degree of phosphatidylcholine unsaturation, and the introduction of antioxidants--SH-compounds, sphingomyelin, phosphatidyl inositol--into liposomes did not influence the efficacy of liposomes.

[Protective effect of phosphatidylcholine liposomes in experimental toxic hepatitis]. / Zashchitnoe deistvie fosfatidilkholinovykh liposom pri éksperimental'nom toksicheskom gepatite.

Level of fructose-1-monophosphate aldolase was decreased in blood serum after administration of phosphatidyl choline-containing liposomes into male rats with experimental toxic hepatitis caused by treatment with hepatotropic poison CCl4 at a dose of 0.25 ml/100 g of body mass. The rate of the aldolase level normalization depends on composition of liposomes as well as on the pathway of their administration.