Squamous cell carcinoma over pilonidal chronic disease. A new therapeutic approach.

INTRODUCTION: Pilonidal sinus is a very common disease. Malignant transformation occurs in 0,1% of patients. We present a case of squamous cell carcinoma arised from recurrent pilonidal disease, managed by multimodal treatment. PRESENTATION OF CASE: We present a 70-year-old man with chronic pilonidal sinus. Inflammation had worsened in previous months and exploration revealed a large ulcerative mass which biopsy showed a squamous cell carcinoma. CT scan and MRI imaging showed tumoral invasion of the coccyx and both gluteus major muscles. Neoadjuvant radiotherapy, chemotherapy as radiosensitizer and surgery with intraoperative radiotherapy was decided in the multidisciplinary tumor committee. Post neoadjuvant therapy MRI showed partial response with a decrease of the mass but persistence of the coccyx infiltration. Surgery consisted in en-bloc resection of the tumor with presacral tissues, coccyx and partial gluteal resection. Intraoperative radiotherapy was administered over the sacrum and in the bed of the coccyx resection. One week later, reconstructive surgery was practiced using a latissimus dorsi free flap, advancement of gluteal flaps and skin graft. Histological examination showed no residual tumor. The patient is currently asymptomatic and he has a satisfactory quality of life. DISCUSSION: Although squamous cell carcinoma is rare, it must be suspected in patients with recurrent pilonidal disease. Diagnosis is done by histological examination of biopsies. This type of tumors have a high local recurrence rate. CONCLUSION: We propose a multimodal treatment that includes neoadjuvant radiotherapy and chemotherapy as radiosensitizer and surgery plus intraoperative radiotherapy with the aim to decrease local recurrence rate.

HIPECT4: multicentre, randomized clinical trial to evaluate safety and efficacy of Hyperthermic intra-peritoneal chemotherapy (HIPEC) with Mitomycin C used during surgery for treatment of locally advanced colorectal carcinoma.

BACKGROUND: Local relapse and peritoneal carcinomatosis (PC) for pT4 colon cancer is estimated in 15,6% and 36,7% for 12 months and 36 months from surgical resection respectively, achieving a 5 years overall survival of 6%. There are promising results using prophylactic HIPEC in this group of patients, and it is estimated that up to 26% of all T4 colon cancer could benefit from this treatment with a minimal morbidity. Adjuvant HIPEC is effective to avoid the possibility of peritoneal seeding after surgical resection. Taking into account these results and the cumulative experience in HIPEC use, we will lead a randomized controlled trial to determine the effectiveness and safety of adjuvant treatment with HIPEC vs. standard treatment in patients with colon cancer at high risk of peritoneal recurrence (pT4). METHODS/DESIGN: The aim of this study is to determine the effectiveness and safety of adjuvant HIPEC in preventing the development of PC in patients with colon cancer with a high risk of peritoneal recurrence (cT4). This study will be carried out in 15 Spanish HIPEC centres. Eligible for inclusion are patients who underwent curative resection for cT4NxM0 stage colon cancer. After resection of the primary tumour, 200 patients will be randomized to adjuvant HIPEC followed by routine adjuvant systemic chemotherapy in the experimental arm, or to systemic chemotherapy only in the control arm. Adjuvant HIPEC will be performed simultaneously after the primary resection. Mitomycin C will be used as chemotherapeutic agent, for 60 min at 42-43 °C. Primary endpoint is loco-regional control (LC) in months and the rate of loco-regional control (%LC) at 12 months and 36 months after resection. DISCUSSION: We assumed that adjuvant HIPEC will reduce the expected absolute risk of peritoneal recurrence from 36% to 18% at 36 months for T4 colon-rectal carcinoma. TRIAL REGISTRATION: NCT02614534 ( clinicaltrial.gov ) Nov-2015.

Uso de la linfogammagrafía intraoperatoria en los casos dudosos de detección del ganglio centinela / Use of intraoperative lymphoscintigraphy in doubtful cases of sentinel node detection

La linfogammagrafía es una técnica ampliamente aceptada para la detección selectiva del ganglio centinela en el melanoma maligno. Presentamos el caso de un paciente intervenido de un melanoma inguinal y que fue remitido al Servicio de Medicina Nuclear para una linfogammagrafía preoperatoria. Existieron problemas técnicos para la detección del ganglio centinela debido a su cercanía con los puntos de inyección. Nosotros planteamos como objetivo la posibilidad de realizar una linfogammagrafía intraoperatoria como técnica válida y de ayuda en casos como el que describimos

Lymphoscintigraphy is a widely accepted method used to detect selectively the sentinel node in malignant melanoma. This is the case report of a patient who was operated on for an inguinal melanoma and who was referred to the Nuclear Medicine Section for preoperative lymphoscintigraphy. There were technical problems for sentinel node detection due to the proximity of injection points. We aimed to know the possibility to perform an intraoperative lymphoscintigraphy as a valid and useful technique in cases as this one

[Use of intraoperative lymphoscintigraphy in doubtful cases of sentinel node detection]. / Uso de la linfogammagrafía intraoperatoria en los casos dudosos de detección del ganglio centinela.

Lymphoscintigraphy is a widely accepted method used to detect selectively the sentinel node in malignant melanoma. This is the case report of a patient who was operated on for an inguinal melanoma and who was referred to the Nuclear Medicine Section for preoperative lymphoscintigraphy. There were technical problems for sentinel node detection due to the proximity of injection points. We aimed to know the possibility to perform an intraoperative lymphoscintigraphy as a valid and useful technique in cases as this one.

Cirugía ambulatoria en tumores cervicales / Ambulatory surgery for cervical tumours

TIPO DE ESTUDIO: Descriptivo PACIENTES Y MÉTODO: Se presentan 10casos de Tumoraciones Cervicales: 3 nódulos tiroideos, 2 quistes tiroglosos,2 adenomas parotídeos,1 Tumor submaxilar, 1 litiasis/abceso submaxilary 1 quiste branquial tratadas en régimen de Cirugía Mayor Ambulatoria. Los criterios de selección varían poco con respecto a los convencionales, así como el tratamiento quirúrgico, ya que solo en las hemitiroidectomías se trataba de evitar la extensión del cuello; y la vigilancia postoperatoria en el Hospital era igual a la que se aplica a cualquier otra patología. Se ha realizado un seguimiento postoperatorio personalizado, en el que el paciente tenía acceso directo a su equipo quirúrgico durante las primeras 24horas postoperatorias. RESULTADOS: Los resultados han sido buenos, ya que no se han producido complicaciones. Se hace una valoración de la actitud con respecto a las complicaciones mas graves que se podían haber producido. Conclusiones: Se concluye que este grupo de patología nodular tiroidea se puede incluir entre las entidades de CMA (AU)

KIND OF STUDY: Descriptive. SETTING: A Public General Hospital. MATERIAL AND METHODS: We present 10cases of Cervical Tumours: 3 thyroid nodules, 2thyroglossal cysts, 2 parotid adenomas, 1 submaxillary tumour, 1 submaxillary lithiasis/abscess and 1 branchial cyst. All these tumours were treated in a Day Surgery Unit (DSU). Both the selection criteria and the surgical treatment hardly differed from that used in conventional procedures except in hemithyroidectomies where we tried to avoid extension of the neck. Postoperative observation during hospital stay was the same as that applied to any other pathology. Personalized postoperative monitoring was carried out allowing the patient to have direct access to his surgical team during the 24 hours following the operation. RESULTS: The results are good as there have been no complications. We evaluated the attitude towards possible complications which mayarise. CONCLUSION: We concluded that this group of nodular thyroid pathology may be included among Ambulatory procedures (AU)