1.
Chemosphere
; 31(2): 2661-8, 1995 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7663950
RESUMO
The urinary metabolites of n-nonane in male Fischer 344 rats, after administering the hydrocarbon by gavage, included gamma-valerolactone, delta-hexanolactone, 2,5-hexanedione, delta-heptanolactone, 1-heptanol, 2-nonanol, 3-nonanol, 4-nonanol, 4-nonanone and 5-methyl-2-(3-oxobutyl)furan. Metabolism strongly favored the formation of monoalcohols and lactones, which are the products of appropriately substituted hydroxy carboxylic acids. The metabolites were identified using gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). High pressure liquid chromatography (HPLC) permitted the detection of the dicarboxylic acids malonic acid and glutaric acid in the n-nonane dosed rat urines.
Assuntos
Alcanos/metabolismo , Álcoois/urina , Alcanos/urina , Animais , Cromatografia Líquida de Alta Pressão , Furanos/urina , Cromatografia Gasosa-Espectrometria de Massas , Hexanonas/urina , Lactonas/metabolismo , Lactonas/urina , Masculino , Ratos , Ratos Endogâmicos F344
2.
Anal Chem
; 59(3): 458-66, 1987 Feb 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-3565764