[Pathomorphosis of rectal cancer after irradiation on the background of intra-arterial regional chemotherapy].

In cancer recti patients, to whom intraarterial chemotherapy, using fluorouracil, was conducted, in the tumour parenchyma the dystrophic, necrobiotic and necrotic changes are prominent, resulting in the ulcer formation, the parenchyma/stroma ratio disturbance with the stroma prevalence, thickening and petrification foci establishment. As well, the lymphocytes and plasmocytes quantity in stroma is enhancing, witnessing the immune reactions activation. Under the influence of fluorouracil the plasmatic infiltration, hyalinosis and the arteriols lumen obliteration occur. The macrophages reaction, the large quantity of a giant multinuclear cells "foreign bodies" occurrence witness the nonviable state of the tumoral cells.

[Application of durable regional intraarterial chemotherapy in complex of treatment of unresectable locally spread rectal cancer].

There in the clinic the method of treatment of inoperable locally spread cancer recti was elaborated, which consists of durable catheterization of superior rectal artery, securing possibility of conduction of several courses of chemotherapy. Using the method of treatment elaborated 33 patients suffering cancer recti were treated in 1996-2006 period. In 29 of them catheterization of superior rectal artery was done during formation of colostoma in conditions of progressing ileus. Partial regression and stabilization of the cancer recti tumor, confirmed by data of roentgenoscopy, colonofibroscopy, computer tomography, were noted in 28 patients. In 2 patients significant tumoral regression was achieved, what have permitted to perform radical operative intervention in some time. Complications, connected with the method application, were absent.