[Modifications of chemical composition of blood serum in chronic nitrate intoxication (experimental research)].

Nitrates (salts of nitric acid) are very common substances in nature and are present in almost all living organisms. Relevance of research about features of various pathological processes in chronic nitric intoxication significantly associated with the fact that the intake of nitro compounds has significantly increased in recent years, especially in rural areas where local water sources are used. Investigations were carried out on 20 white Wistar rats. Two series of the experiment ware held: Group I - intact animals (10 animals); Group II - animals after administration of sodium nitrate at a dose of 200 mg/kg in the form of an aqueous solution intragastrically for 60 days (10 animals). Chronic nitrate intoxication leads to a significant increase of the level of serum chondroitin rats with permanent indicators glycoproteins indicates that the products disorganization of proteoglycans from the bone to the blood serum. Increasing of overall level glycosaminoglycans and the third fraction (heparan sulfate), and reducing of the 2-nd fraction (chondroitin-4-sulfate) glycosaminoglycans in serum may be indicative of a chronic lesion of sodium nitrite intoxication general connective tissue (including bone tissues and liver parenchymal).

[Prevalence of arterial hypertension and efficacy of long-term multifactor prophylaxis in some regions of Russia].

AIM: To study prevalence of arterial hypertension (AH) in relation to gender, age, profession, risk factors (RF), RF combination; efficacy of active long-term multifactor prevention among the employees of industrial enterprises in some regions of Russia. MATERIAL AND METHODS: 14000 males and 20969 females from industrial enterprises of Cheboksary, Pskov, St-Petersburg were examined. 8974 males and 14515 females worked at enterprises of active intervention (EAI) while 1848 males and 1643 females were employed at comparison enterprises. RESULTS: Correction of RF conducted at six EAI reduced a mean level of systolic blood pressure (SBP) and diastolic blood pressure (DBP), frequency and intensity of smoking, overweight and cases of RF combination, improved ECG parameters, wellbeing of hypertensive patients, increased number of examinees free of risk factors, decreased number of days of temporary disability. Among EAI employees overall mortality, ishemic heart disease mortality and cerebrovascular disorders fell. CONCLUSION: Five- and 10-year active multifactor office prophylaxis resulted in reduction of the rate and intensity of RF, number of temporary disability days by 48%. Arterial hypertention, combination of RF in healthy and hypertensive subjects at the start of the trial significantly promoted high all-causes and cardiovascular mortality at all enterprises studied. Active multifactor prophylaxis reduced those mortalities significantly.

[Apoptosis in the cells of parenchymatous organs in subacute sodium nitrate poisoning]. / Apoptoz v kletkakh parenkhimatoznykh organov pri podostroi intoksikatsii nitratom natriia.

Subacute intoxication was induced by the oral administration of sodium nitrate 200 mg/kg during 150 days to Wistar rats. After the time had been up severe damaging were found in liver, kidney, heart and thymic tissues. In the liver cells the DNA fragmentation in "scale" manner was found, but not in kidney and heart cells. Simultaneously, the Ca2+, Mg(2+)-depended endonucleases activity were increased in the liver nuclei extracts under intoxication. It was suggested that increasing of apoptosis in liver is the universal reaction to toxins.

[The sources of active forms of oxygen in the normal oral tissues and in pathology]. / Istochniki aktivnykh form kisloroda v tkaniakh rotovoi polosti v norme i pri patologii.

In the experiment on rats the changes of the superoxydanionradical production from microsomal and mitochondrial oxidation and tissue phagocytes of the saliva gland and parodontium in contact sialadenitis, spontaneous parodontitis, after ionizing radiation have been investigated. It is supposed that an increase or decrease of superoxydanionradical production from different sources demands a differentiated corrective approach.