[Alexithymia in women after myocardial infarction: the role of neurophysiological correction method in complex sanatorium rehabilitation].

The article is dedicated to analysis of psychological features of 152 women with coronary artery disease (CAD), who had had acute myocardial infarction and had begun sanatorium rehabilitation in Belokurikha sanatorium. The role of the neurophysiological method of bioadaptive regulation in improvement of the efficacy of early post-infarction rehabilitation and secondary CAD prophylaxis in women with alexithymia was evaluated. The authors make their conclusion on the basis of clinico-functional and psychological studies and statistical evaluation of the data received in the course of the study. The study demonstrated full reestablishment of functional reserve, the presence of psychoemotional relaxation, compensation of complications, and mobilization of psychological resourse in patients with alexithymia whose sanatorium rehabilitation program included psychotherapy with biological feedback trainings.

[Insulin-glucose parameters in healthy women and patients with arterial hypertension and ischemic heart disease in dependence on age and follicle-stimulating hormone levels].

Insulin-glucose parameters in healthy women do not significantly change with changes of functional state of ovaries. Women with hypertension and normal levels of glycemia have significantly higher values of basal insulinemia and HOMA-R index reflecting presence of moderate insulin resistance degree of which is more pronounced in middle aged patients. In women with documented ischemic heart disease values of basal insulinemia, HOMA-R index, and glycemia are comparable with those in patients with hypertension and follicle-stimulating hormone level above 30 IE/l and significantly differ from corresponding parameters in healthy women in peri- and postmenopause.

[Use of resort factors in Novosibirsk region in the treatment of digestion system diseases].

Hydrocarbonate-chloride-sodium mineral water has a prokinetic effect, reduces lithogenicity of bile and decreases the level of glycoproteins in biological fluids improving their rheological characteristics. Saline "rapa" baths decrease intragastric pH, stimulate pancreatic secretion, normalize mucus composition and activate protective-adaptive mechanisms of organism. Pelotherapy modulate gastric juice acidity making antigelicobacteria effect and decrease glycoproteins concentration of digestive sectets.

[Coronary atherosclerosis and total serum cholesterol in men and women].

The study shows that the extent of atherosclerotic changes in the coronary arteries, revealed during coronaroangiography, has a significant correlation with the serum level of total cholesterol (TC). In patients with normal (less than 5.2 mmol/ l) TC the number of involved arteries and the number of stenotic segments are significantly smaller than those in patients with a TC level higher than 6.5 mmol/l.

[Hormone-producing function of the ovaries in young and middle-aged women with arterial hypertension and coronary heart disease].

The study demonstrates that arterial hypertension itself, judging by main anthropometric variables such as body weight index and waist to hip ratio, together with the estrogen-producing function of the ovaries, evaluated by measuring follicle-stimulating hormone levels, contributes substantially to the forming of abdominal obesity in normo- and hypertensive women. All the above confirms close correlation between hemodynamic and metabolic disturbances which eventually result in coronary heart disease in young and middle-aged women.

[The role of leukocytes in mechanism of action of balneopeloidotherapy]. / Rol' leikotsitov v mekhanizme deistviia bal'neopeloidoterapii.

Treatment with alkaline sulfide mud activates oxidant activity of neutrophils which stimulate body defense and adaptation but can provoke balneoreactions. Lysosomic membranes remain stable as mud does not stimulate phagocytosis. Peloid therapy stimulates a monocytic (macrophagal) lineage of hemopoiesis directed to elimination of intracellular microflora and products of inflammation. Radon therapy depresses oxidant and non-oxidant neutrophil activity thus diminishing damage to tissues and vessels and relieving inflammation.

[On the possible prooxidant role of insulinemia in formation of metabolic syndrome in men and women.]. / O vozmozhnoi prooksidantnoi roli insulinemii v formirovanii metabolicheskogo sindroma u muzhchin i zhenshchin.

Levels of basal insulinemia, malondialdehyde (an index of oxidative stress) and some metabolic parameters were studied in 143 men and 83 women aged 48.3+/-0.7 years with incomplete metabolic syndrome: hypertension, abdominal obesity, dyslipoproteinemia with normoglycemia. Basal insulinemia correlated significantly with malondialdehyde levels both in men and women. Slose relationship was also found between basal insulinemia and waist circumference.

[Myocardial infarction in women: risk factors and clinical features]. / Faktory riska i osobennosti techeniia infarkta miokarda u zhenshchin.

The course of myocardial infarction (MI) in women, especially 60 years of age and older, is characterized by such severe complications as cardiorrhexis, hypovolemic cardiogenic shock, asystole, recurrent ventricular fibrillation and electromechanic dissociation responsible for the majority of lethal outcomes. Especially high MI lethality is in women at the age 70-79 years who have also the highest incidence of recurrent macrofocal MI while small-focal MI occurs in women over 80 years of age (80-89) more frequently than in 60-year-olds and younger. Dominating MI risk factors in women were the following: arterial hypertension detected in 81% patients under 60 and 90.8% cases over 60 years; abnormal lipid spectrum of blood including hypercholesterolemia (HCE), hypertriglyceridemia (HTE) and low concentration of HDLP cholesterol. HCE and HTE closely correlated with abdominal obesity irrespectively of age. Early menopause in women under 60 and diabetes mellitus of type 2 in older women, accumulation of two and more factors of risk contribute to development of coronary heart disease and MI, in females.

[Etio-pathogenetic mechanisms of recurrences of atrial fibrillation of toxic alcoholic origin]. / Etiopatogeneticheskie mekhanizmy retsidivirovaniia fibrilliatsii predserdii alkogol'no-toksicheskogo geneza.

The following conditions in patients with alcoholic cardiac involvement predispose to recurrences of atrial fibrillation: atrial dilatation, shortening of refractory period, slowing of atrial conduction, increased vulnerability to extra stimuli, appearance of fragmented electrical activity i.e. late atrial potentials on high resolution ECG, autonomic influences on the heart, hypokalemia and hypomagnesemia.

[Predictive value of insulin-glucose homeostasis markers in patients with metabolic syndrome X]. / Analiz informativnosti pokazatelei insulingliukoznogo gomeostaza u bol'nykh s metabolicheskim sindromom X.

AIM: To clarify informative value of secretory ability of pancreatic beta-cells and correspondence of insulin values to glycemia in the course of standard glucose tolerance test (GTT) in detection of insulin-resistance in patients with arterial hypertension (AH) to verify metabolic syndrome (MS). MATERIAL AND METHODS: Correlation and factor analyses were performed of correlations between glycemia, immunoreactive insulin (IRI), C-peptide, glucose/IRI in the course of GTT in 111 AH patients divided into groups by the sum of metabolic disturbances. RESULTS: The greatest number of correlations were seen for glucose/IRI fasting index. According to the factor analysis, changed sensitivity to insulin and hyperinsulinemia are the first stage of metabolic disturbances in AH irrespective of body mass. In obesity the number of the above correlations is maximal. Multivariance analysis has shown significant differences between AH patients and healthy subjects irrespective of body mass and glucose tolerance. CONCLUSION: Basal index glucose/IRI < 6 relative units is informative in all the studied variants of metabolic syndrome as regards insulin resistance.

[Predictors of ventricular tachycardia in patients with mitral prolapse]. / Prediktory vozniknoveniia zheludochkovykh takhikardii u bol'nykh s prolapsom mitral'nogo klapana.

128 patients with primary mitral prolapse and 72 healthy controls were examined using noninvasive methods. The analysis of the findings revealed predictors of electric myocardial unstability: reduced variability of cardiac rhythm, diastolic left ventricular dysfunction, late ventricular potentials and growing dispersion of the Q-T interval. Detection of mitral regurgitation correlates with development of ventricular arrhythmia.

[Factors affecting onset of ventricular arrhythmias and sudden death in patients with dilated cardiomyopathy]. / K voprosu o faktorakh, vliiaiushchikh na vozniknovenie zheludochkovykh aritmii i vnezapnoi smerti u bol'nykh s diliatatsionnoi kardiomiopatiei.

The study of 46 patients suffering from dilated cardiomyopathy has shown that both ventricular tachycardias detected at 24-h ECG monitoring and late ventricular potentials are essential predictors of sudden arrhythmic death. These predictors depend neither on severity of left ventricular systolic and diastolic dysfunction nor on severity of cardiac decompensation.

[Variants of hyperosmolarity syndrome in diabetes mellitus patients in critical conditions]. / Varianty giperosmoliarnogo sindroma u bol'nykh sakharnym diabetom v urgentnoi terapevticheskoi klinike]

Recently, high lethality of critical conditions in diabetes mellitus patients has been attributed to the presence of hyperosmolarity syndrome. The authors consider this problem in terms of plasm osmolarity parameters, pathogenesis and diagnostic criteria of hyperosmolarity. Present-day clinical variants of hyperosmolarity syndrome are characterized.

[Determination of myoglobin concentration in blood in the diagnosis of unstable (progressive) angina pectoris]. / Opredelenie kontsentratsii mioglobina v krovi v diagnostike nestabil'noi (progressiruiushchei) stenokardii.

A survey of 180 patients with unstable angina pectoris has demonstrated that transient hypermyoglobinemia detected in 58% of patients is a more informative parameter than those obtained with electrographic and enzyme immunoassay used in the diagnosis of focal alterations in the heart muscle in the disease. Measurement of serum myoglobin levels by rapid radioimmunoassay in these patients is of predictive value as it allows a group of subjects at high risk for myocardial infarction to be identified.

[Lipid composition of blood sera of elderly and long-lived healthy and sick individuals]. / Lipidnyi sostav syvorotki krovi u zdorovykh i bol'nykh starcheskogo vozrasta.

Serum cholesterol (SC), HDL SC and triglycerides were measured in 303 senile patients aged 75-89 and 77 long-livers aged over 90. The concentrations obtained were low in healthy long-livers compared to senile subjects. SC, triglycerides and atherogenic index reached the highest values in senile subjects and long-livers with coronary heart disease and abnormal cerebral circulation. Lower levels of HDL SC appeared in the same diseases in senile males and female long-livers against healthy subjects of the relevant age group.

[Responsiveness of peripheral blood vessels to physiologically vasoactive agents in myocardial infarct]. / Reaktivnost' perifericheskikh sosudov po otnosheniiu k fiziologicheskimvazoaktivnym veshchestvam pri infarkte miokarda.

Changes in skin vascular responsiveness (VR) to six vasoactive agents were examined in 25 patients with myocardial infarction during its acute period. In small myocardial infarction, there was a synchronous increase in all VR types on days 1-7 followed by its normalization on day 14. VR synchronization was also observed in transmural myocardial infarction, yet increased VR to vasoconstrictive agents such as noradrenaline, adrenaline, and angiotensin II remained until the end of the fourth week without showing a tendency to normalization. Abnormal VR was seen in the most severe fatal cases. The synchronous and cyclic VR changes observed in myocardial infarction were absent in patients with unstable angina that did not result in myocardial infarction.