Hyperbaric oxygen therapy as salvage treatment for sudden sensorineural hearing loss: a prospective controlled study.

The most commonly used treatment for sensorineural sudden hearing loss (SSHL) in clinical practice is the administration of steroids; however, a favorable result is not always obtained. We studied 58 patients who failed to recover after primary treatment with IV steroids, 44 of these met our inclusion criteria (mean age 50.7, 27 males, range 30-74). We treated 23 patients (mean age 47.3, 16 males, age range 22-74) with hyperbaric oxygen therapy (HBO) (2.5 ATA for 60 min for 15 treatments), while 21 (mean age 54.5, 11 males, age range 22-71) patients refused to be treated and served as a non-randomized control group. Patients treated with HBO had a mean improvement of 15.6 dB (SD ± 15.3), with 1 of them completely healed, 5 with a good recovery, 10 with a fair recovery and 7 unchanged. Patients who were not treated had a spontaneous mean improvement of 5.0 dB (SD ± 11.4) with 3 patients with a good recovery, 1 patient with a fair recovery and 17 patients unchanged. Mean improvement was significantly better in patients treated with HBO compared to controls (p = 0.0133). Patients with worst hearing had the greater degree of improvement whether or not they were treated in the first 10 days after the onset of the hearing loss or between 11 and 30 days. In conclusion, hyperbaric oxygen therapy can lead to significant improvement of pure tone hearing thresholds in patients with SSHL who failed primary corticosteroid treatment and are within 4 weeks of the onset of deafness.

[Differential diagnosis in fibro-osseous lesions of facial bones: report of a case of ossifying fibroma and review of literature]. / Diagnosi differenziale delle lesioni fibro-ossee delle ossa del massiccio facciale: descrizione di un caso clinico di fibroma ossificante e revisione della letteratura.

Ossifying fibroma is a relatively rare, benign neoplasm of non-odontogenic origin, affecting the facial bones, and prevalently localized in the mandible, but which can also appear in the maxilla, paranasal sinuses and peripheral bones. Its growth is generally very slow and it is usually asymptomatic, for which it often manages to reach a considerable size. An incidental diagnosis during orthopantography, on the other hand, is not infrequent. The diagnosis, which is fundamentally made by utilizing conventional x-rays and CT and NMR scans, may present several controversial aspects and is not to be disjointed from the clinical and anatomopathological aspects, for which close interdisciplinary collaboration is required in many cases. In effecting a differential diagnosis, the possibility of inflammatory lesions, other fibrous-osseous lesions (in particular, fibrous dysplasia) and benign or malignant neoplasms must be taken into consideration. The present work presents a case of ossifying fibroma of the maxilla that is emblematic in its clinical, radiological and histopathological aspects. It also discusses problems connected with classification and differential diagnosis, in particular with respect to fibrous dysplasia, which are important in determining the proper therapeutic approach.

A physical-based model for the simulation of neoplastic growth and metastasis.

BACKGROUND AND OBJECTIVES: It is possible to formulate models capable of reproducing the main details of the physical processes involved in the evolution of biological systems. The complexity of the problem requires to begin with a simple and universal model for the description of the cellular growth, to be adapted successively to the local conditions found in clinically observed neoplastic growths. METHODS: A model based on the Local Interaction Simulation Approach (LISA) has been formulated for the simulation of growth, diffusion, and metastasis of neoplasms. The vascularization is described by a blood vessel located on one edge of the specimen in which a constant and homogeneous flow is assumed. A nutrient density is defined to mimic the blood flow within the tissue. RESULTS: Photograms taken at proper times may identify the main characteristics of the tumor evolution and describe its volume variations in a transversal section. Furthermore, it is possible to monitor constantly the volume of the neoplasm and of the necrotic tissue as a function of time, as well as the portion of cells that have migrated in the blood vessel. CONCLUSIONS: In spite of strong simplifying assumptions, the model presents good qualitative agreement with clinical data, which may be further improved by more detailed information about cancer cells properties or local vascular system patterns.

Lymphnode metastasis in head and neck squamous cells carcinoma: multivariate analysis of prognostic variables.

Cervical lymphnodes metastatization by the squamous cell carcinoma of the head and neck is well known as a prognostic negative factor as far as survival is concerned. Multivariate analysis has been used on 207 cases of head and neck squamous cell carcinomas (HNSCC) in order to identify the possible prognostic significance of a group of clinical and histopathological characteristics, aiming to find a correlation with the possible occurrence of cervical lymphnodes. Two hundred and seven patients (168 males and 39 females, mean age: 62 years) with SCCHN were studied. They underwent surgery alone and radiotherapeutic associated treatment. Variables regarding the patient, carcinoma and histology were analysed: age, sex, smoking and alcohol consumption, performance status, concomitant internal pathologies (cardiopathies, hepatopathies, broncho-pneumopathies, metabolic disorders), site and size of primary tumor (T stage), number and size of laterocervical lymph node localization (clinical N stage), grading, vascular permeation, perineural infiltration. Multivariate analysis of prognostic factors was performed using BMDP's PLR programme. Some variables showed a great risk of lymphnode metastasis; among sites: supraglottic larynx (p = 0.05), base of the tongue (p = 0.04), hypopharynx (p = 0.05); some histological parameters as lower degree of histological differentiation (p = 0.02), the presence of vascular permeation (p = 0.06) and perineural invasion (p = 0.07) appear to represent predisposing factors for the onset of adenopathies. By considering prognostic factors as shown, it is possible to better identify metastasis risk cases, that leads to improved therapeutical strategies.

Results of chemotherapy plus external reirradiation in the treatment of locally advanced recurrences of nasopharyngeal carcinoma.

Between 1982 and 1991, 16 patients with recurrent cancer of the nasopharynx were treated with chemotherapy (CT) and radiotherapy (RT). All patients had received prior RT (45-69, 30 Gy). According to rTNM there were three rT2, one rT3 and 12 rT4. 5 patients were N1. Reirradiation (12-46 Gy, mean: 28) started 3-4 weeks after CT (2-6 cycles of different combinations), but 2 cases involved concomitant therapy. Out of 16 patients 7 had complete response (CR) (43.7%), 7 partial response and 2 no response. Statistically significant prognostic factors for obtaining CR were time of relapse and response to initial CT. Median duration of CR was 22+ months (9-64+). Failures at primary site occurred in 3 patients, 2/2 of those receiving CT without platinum compounds and 1/5 of other ones, with statistically significant difference in local recurrence free-survival between the two groups. Two- and 3-year actuarial overall survival were 28% and 10%. Rates of disease-free survival were 17% and 8%, respectively. The acute toxicity was generally mild. No central nervous system damage or radiation-induced myelitis were observed in survivors.

[Electrogustometry. Presentation of a new electrogustometer]. / A proposito dell'elettrogustometria. Presentazione di un nuovo elettrogustometro.

A new electrogustometer containing variations dictated by clinical practice is presented. Technical innovations are presented and discussed together with application of the technique in the study and prognostic assessment of peripheral paralysis of the facial nerve. Some results obtained in clinical practice in the same pathology with different aetiology are discussed.

Influence of perioperative transfusion therapy on the recurrence potential of locally advanced laryngeal carcinoma.

The present study was undertaken to determinate whether immunosuppression, induced by perioperative allogenic whole-blood transfusions (AWBTs), adversely affects prognosis after total resection of laryngeal cancer by promoting the appearance of recurrences. We studied 62 patients, aged 37-82 years with TNM stage III and IV (UICC, 1987) laryngeal cancer treated between 1977 and 1983. AWBTs were administered to 30/62 patients perioperatively. All patients were followed up for 4 years. After 4 years we found the following disease-free survival indexes: transfused, 12/30 (40%); nontransfused, 22/32 (70%; p less than 0.05). On the base of these dates, we conclude that AWBTs exert a significant influence on early recurrence and on survival in patients with laryngeal cancer.