1.
Br J Haematol
; 81(3): 453-4, 1992 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-1390224
2.
Mol Gen Genet
; 190(3): 523-6, 1983.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6348484
RESUMO
Spontaneously-occurring rifampicin-resistant mutants that survive on low (20 micrograms ml-1) but not high drug concentrations (200 micrograms ml-1) have been isolated. One such mutation appears to map close to residue 650 on the beta structural gene. RNA polymerase from low-level resistant strains shows an intermediate response to rifampicin in vitro: both the association and dissociation rates of the antibiotic are markedly reduced. Continued expression of this unusual phenotype upon introduction of a high-level resistance allele is described in terms of DNA blockade.