[Natural suppressors of the human bone marrow tissue]. / Estestvennye supressory kostnomozgovoi tkani cheloveka.

Proved the investigation devoted to the natural suppressors of healthy donors, patients with acute leukosis and solid tumors. The author made a comparative densitometric analysis of the bone marrow cells in these group.

[Immunodepressants used in immune system pathology. I. Cyclosporin, cyclophosphane, azathioprine and mercaptopurine]. / Immunodepressanty, primeniaemye pri patologii immunnoi sistemy. I. Tsiklosporin, tsiklofosfan, azatioprin, merkatopurin.

The data on immunodepressants most commonly used in the Soviet Union in the diseases caused by disorders in normal function of the immune system are presented. Such drugs as cyclosporine A, cyclophosphan, azatioprine, 6-mercaptopurine are considered. Emphasis is given to the mechanism of the primary pharmacological response of the drugs to the immunocompetent cells, the grounding of their clinical use, dosage and mechanisms of possible side effects.

[Separation of bone marrow cells in a Percoll discontinuous density gradient]. / Separatsiia kletok kostnogo mozga v stupenchatom gradiente plotnosti perkolla.

Human bone marrow cells were separated by centrifugation in percoll discontinuous density gradient with 1.020-1.080 g/ml densities. CFU-GM test and EPICS analysis were used to characterize cell compositions of the resultant fractions. The employed mode of separation permits obtaining cell fractions rich for monocytes, macrophages, T and B lymphocytes.