RESUMO
The evidence has been produced that immunological mechanisms are involved in the known anticancer phenomenon of T. cruzi. Non-inbred albino mice were immunized with avirulent cultures of three strains and seven clones and then transplanted a tumor--sarcoma-180 or Ehrlich's adenocarcinoma. The used cultures induced the generation of T. cruzi antibodies whose level peaked by postimmunization days 50-60: the titers being 1:40-1:80 and the spread among the mice being 60%. Concurrently, immunization against T. cruzi provided a certain oncoprotective effect. In the immunized mice, the sizes of sarcoma-180 and adenocarcinoma were 1.5-2.0 and 2.0-2.5 times, respectively, less than those in the non-immunized ones. The antitumor protection was directly related to the murine blood T. cruzi antibody level during which implantation of a tumor occurred. At the peak of an immune response, the effect was 2 times higher than that in the early postimmunization periods. T. cruzi strains that were more immunogenic than clones ensured a more significant oncoprotection. The latter was more considerable in mice having antibody titers of 1:40-1:80 than in those with antibody titers of 1:10-1:20 and particularly in the animals showing no humoral response to the administration of the parasites at all.
Assuntos
Adenocarcinoma/prevenção & controle , Doença de Chagas/imunologia , Imunização , Vacinas Protozoárias/administração & dosagem , Sarcoma Experimental/prevenção & controle , Neoplasias Cutâneas/prevenção & controle , Trypanosoma cruzi/imunologia , Animais , Anticorpos Antiprotozoários/sangue , Injeções Intramusculares , Injeções Intraperitoneais , Injeções Subcutâneas , Camundongos , Especificidade da Espécie , Fatores de Tempo , Vacinas Atenuadas/administração & dosagemAssuntos
Perda de Dente/epidemiologia , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Saúde Bucal , Distribuição Aleatória , Fatores de Risco , Federação Russa/epidemiologia , Distribuição por Sexo , Perda de Dente/etiologiaRESUMO
The rate of consultations of elderly and senile patients applying for dental care is analyzed. A total of 510 patients aged 60 years and more who applied to a municipal dentistry center in the southeast region of Moscow were examined. The number of visits to dentist did not depend on age and sex. A notable difference was detected between the rate of consultations for subjects with intact natural teeth and patients who lost natural teeth.