[Comparative characteristics of the immunotropic activity of sodium diclofenac, indomethacin and sodium salicylate]. / Sravnitel'naia kharakteristika immunotropnoi aktivnosti natriia diklofenaka, indometatsina i natriia salitsilata.

It has been shown in experiments on mice that sodium diclofenac and indomethacin inhibited antibody titers and the number of rosette-forming cells (RFC) in mice immunized with sheep red blood cells. Sodium salicylate in all test doses did not produce any shifts in rosette-formation but lowered the number of RFC. As regards the immunodepressant activity, sodium diclofenac compares very favourably with indomethacin and sodium salicylate. Enhancement of the immunoreactivity inhibition caused by the drugs was not proportional to the increase in their antiphlogistic effects determined by the Selye model of inflammation.

[Effect of inducers of mixed-function microsomal oxidases on the immune response of mice induced by heterologous erythrocytes]. / Vliianie induktorov mikrosomal'nykh oksidaz so smeshannoi funktsiei na immunnyi otvet myshei, vyzyvaemyi geterologichnymi éritrotsitami.

In experiments on male white mice immunized with sheep red blood cells the influence of various substances, differing in their chemical composition and biological activity, on the antibody titers and the number of rosette-forming cells in the spleen has been studied. These substances, acting as inductors of microsomal oxidases with mixed function (cytochrome P-450 and P-448), are phenobarbital, 3-methylcholanthrene, DDT, diphenin, rifampicin, benzodiazepin derivatives (diazepam and phenazepam). All monoxygenase activity inductors have been shown to exert a more or less pronounced immunosuppressive effect. Thus, reciprocal relations between the induction of monoxygenases and the induction of immune response have been established. The results obtained in this research are discussed from the viewpoint of the new hypothesis stating that immunity is one of the functions of the general system metabolizing chemical compounds in the body.

[Pharmacologic activity of pyrimidoindole derivatives]. / Farmakologicheskaia aktivnost' proizvodnykh pirimidoindola

The spectrum of the psychotropic activity of a number of new pyrimidoindole derivatives and the relation between their chemical structure and activity were studied experimentally. The research was done on mice by employing tests usually applied in estimating neuroleptics and antidepressants of tricyclic structure. The study of indole derivatives are shown to display a sedative action. 5-methyl derivatives of pyrimido- and tetrahydropyrimido [3,4-a] indole without any substituent in the 2nd position are 5-oxytryptophan antagonists. The 2,5-dimethyltetrahydropyrimido [3,4-a] indole derivatives electively potentiate the central effect of 5-oxytryptophan and display in experiments a specific spectrum of the pharmacological action, resembling antidepressants by a number of tests. As concerns their activity these compounds, however, are inferior to amitriptyline and pyrasidol.