[The role of immunocytes in the production of interferon in response to its induction by aromatic hydrocarbons]. / Uchastie immunotsitov v produktsii interferona v otvet na induktsiiu aromaticheskimi uglevodorodami.

Interferon (IF) was synthesized in animals by diverse populations of immunocytes in response to induction by various low molecular weight aromatic hydrocarbons. The level of the involvement of either population of the immunocytes in IF production is determined by the chosen inductor. IF induction by acridanone L-1 was mainly observed in macrophages and B-lymphocytes. T-Cells actively participated in IF synthesis induced by amyxin, a representative of the fluorenone group. IF synthesized by lymphocytes of human peripheral blood in response to L-1 was completely neutralized by antiserum to alpha-IF while IF induced by amyxin in the same culture was a mixture of alpha- and beta-IFs at a ratio of 3:1.

[The comparative characteristics of the interferon-inducing capacity of 2 preparations related to aromatic hydrocarbons]. / Sravnitel'naia kharakteristika interferonindutsiruiushchei sposobnosti dvukh prparatov, otnosiashchikhsia k aromaticheskim uglevodorodam.

Aromatic hydrocarbons are rightly considered to belong to most active synthetic interferon inducers among low molecular compounds. A comparative evaluation of L-1 (acridanon) and amixin (fluorenon) showed L-1 to have more marked interferon-inducing properties. Both compounds differed not only in the dynamics and levels of interferon synthesis in different organs which suggests the possibility of their employment in different diseases, but also in the efficacy of the modes of application. L-1 induced IF synthesis most actively after subcutaneous inoculation, amixin after oral administration.