[Development of concepts on the biochemistry and pharmacology of melanin pigments]. / Razvitie predstavlenii o biokhimii i farmakologii melaninovykh pigmentov.

Biochemical principles of pharmacological action melanin, one of the natural cells pigments, are discussed. Melanin is involved into DNA-repair, in the the respiratory chain functioning; it modulates such important systems of the cellular metabolism as photo- end radio protectors. Melanin neutralizes the effect of products of lipid peroxidation and takes part in neurotransmitter processes under numerous pathological processes damaging functional neuron structures. Experimental data cannot often account for the mechanisms of melanin action and therefore systematic analysis of all the data published on melanin pigments is necessary for possible employment of melanins for the pharmacological needs.

[The modifying action of a complex of physiologically active substances isolated from the human amnion on chromosome damage]. / Modifitsruiushchee vliianie kompleksa fiziologicheski aktivnykh veshchestv, vydelennykh iz amniona cheloveka, na povrezhdenie khromosom.

It was determined that the complex of physiological active substances separated from human amnion reduced the frequency of the hepatocytes with chromosomal aberrations in rats. This reduction of chromosomal damages was noted at spontaneous and induced mutagenesis. The value of cytogenetical effect, the availability of raw material and the natural origin of the drug allow to propose it for further study and use as modifier of mutagenic action.