[Emphysematous pyelonephritis]. / Emfysematøs pyelonefritis.

Emphysematous pyelonephritis (EPN) is a rare, life-threatening infection of the kidney, characterized by production of gas within the renal parenchyma or perinephric tissue. Escherichia coli and Klebsiella are the most commonly isolated organisms. Most patients are diabetics. CT is diagnostic. Within half a year two patients with EPN were admitted. They were successfully treated with internal/percutaneous drainage (PCD), and antibiotics. Earlier, acute nephrectomy was first choice treatment, but recent studies point towards PCD and antibiotics as a better alternative.

Validity of a self-administered questionnaire, with reference to a clinical stress urinary incontinence test.

OBJECTIVE: To estimate the criterion validity of a self-administered questionnaire on urinary incontinence (UI) using a clinical stress UI test as reference. MATERIAL AND METHODS: A total of 4710 women aged 20-59 years randomly selected from the municipalities of Aarhus and Randers (Denmark) participated in a population survey on UI. A sub-sample of 96 women stratified by the duration and frequency of UI answered an assisted, self-administered questionnaire concerning UI during the preceding 6 months. Subsequently, a clinical stress UI test was performed with the researchers being blinded with regard to the questionnaire information. RESULTS: Based on the clinical stress test and questionnaire, 22 (22.7%) and 21 women (21.6%) had stress UI, respectively. UI occurring in more than drops and UI lasting for > 4 weeks were found to be adequate predictors of UI (odds ratio 8.9 and 4.6; p < 0.001 and p < 0.05). Regarding all forms of UI, the agreement between the stress UI test result and the questionnaire data ranged from 51.0% to 77.1%. The probability of finding a positive stress UI test was 62% among women who answered that UI had lasted for > 4 weeks and occurred in more than drops, compared to 22.9% in the total study group. The sensitivity and specificity of the stress UI test among women in whom UI lasted for > 4 weeks and occurred in more than drops were 22.7% and 95.9%, respectively. CONCLUSIONS: These findings suggest that there is a greater probability of finding severe UI if the women have experienced it in more than drops and it has lasted for > 4 weeks and it is therefore necessary to estimate the degree of incontinence further by means of a stress UI test. In contrast, women who experienced UI in less than drops and for a duration of < 4 weeks only suffered from a very mild degree of UI.

Retroperitoneal dismembered pyeloplasty: initial experiences.

AIM: To review the results of our first 40 cases of retroperitoneal dismembered pyeloplasty and to compare them with series of open and other minimally invasive treatments of pelviureteric junction (PUJ) obstruction. Also to compare our first 20 cases with the second 20 cases to see if there was an improvement in results with experience. METHODS: A retrospective review of the first 40 laparoscopic pyeloplasties performed by a single lead surgeon at two institutions was performed. The diagnosis of PUJ obstruction was confirmed with an intravenous urogram as well as a renogram prior to surgery. A retroperitoneal, dismembered pyeloplasty was routinely performed with three or four ports. All patients were followed up with an intravenous urogram, renogram and review of symptoms at 4 months and annual renogram after that. RESULTS: Average operation time was 236 min and this appeared to decrease with experience. Two cases had to be converted to open operations. The mean hospital stay was 3.4 days. Out of the 40 patients, 34 have had successful laparoscopic operations with total symptomatic relief as well as radiologically proven deobstruction. There were four major complications with 3 patients going on to have redo open pyeloplasty operations. There were seven minor complications. CONCLUSIONS: In our experience, retroperitoneal dismembered pyeloplasty is an effective and safe means of treating PUJ obstruction. Our results seem to be comparable with series of open pyeloplasty and other laparoscopic series and are better than some other minimally invasive techniques.

Prostate tissue and leukocyte levels of n-3 polyunsaturated fatty acids in men with benign prostate hyperplasia or prostate cancer.

OBJECTIVE: To compare the levels of n-3 polyunsaturated fatty acids (PUFAs) in leukocytes and prostate tissue in men with prostate cancer or benign prostatic hyperplasia (BPH), as dietary intake of n-3 PUFAs has been linked to the risk of prostate cancer; the prostate-specific antigen (PSA) level was also compared to prostate tissue levels of n-3 PUFAs. PATIENTS AND METHODS: Prostate tissue was obtained and leukocytes isolated from 20 men with prostate cancer and 35 with BPH. The n-3 PUFAs alpha-linolenic acid (ALA), eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA) were measured in prostate tissue and in peripheral blood leukocytes using gas chromatography. PSA levels were measured in all of the men. RESULTS: There was a strong positive correlation between EPA and DHA in leukocytes and in prostate tissue (EPA: r = 0.80, DHA: r = 0.53, both P < 0.001) in all the men, whereas there was no association between the content of ALA in leukocytes and in prostate tissue (r = -0.15). Men with BPH had similar levels of ALA in leukocytes and in prostate tissue, but men with prostate cancer had more ALA in prostate tissue than in leukocytes. The PSA level was significantly positively correlated with ALA level in prostate tissue (r = 0.42, P < 0.01) but there was no significant correlation between PSA level and EPA and DHA levels. There were no significant correlations between PSA level and n-3 PUFA levels in leukocytes. CONCLUSION: Dietary intake of the marine n-3 PUFAs reflected in EPA and DHA levels in leukocytes are also reflected in EPA and DHA levels in prostate tissue in men with and without prostate cancer. However, there is a discrepancy between the levels of ALA in leukocytes and in prostate tissue, with higher levels in men with prostate cancer. This is in accordance with the strong positive association between PSA and ALA levels in prostate tissue. This study therefore does not support the hypothesis that intake of marine n-3 PUFAs might protect against prostate cancer, but lends support to the deleterious role of ALA in the development of prostate cancer.

Results in 32 women operated for genuine stress incontinence with the pubovaginal sling procedure ad modum Ed McGuire.

OBJECTIVE: To determine the efficacy of the sling procedure in curing genuine stress incontinence in women. PATIENTS AND METHODS: Thirty-two women underwent the pubovaginal fascial sling procedure because of genuine stress incontinence. Currently, the patients are still monitored in order to check the efficiency of the treatment. RESULTS: The patients have been followed for a period of 5 years, and 30 patients are cured from stress urinary incontinence. One patient is improved, one is lost to follow up. Five patients experience intermittent minor degree of urge incontinence. Two patients have to perform clean intermittent catheterization (CIC) from time to time; one also did this before the operation. CONCLUSION: The sling procedure is a superior operation for patients that suffer from genuine stress incontinence, and should be the first choice of treatment.