RESUMO
Integrins are glycoproteins of dimeric structure and promote the binding between the cytoplasm and the Intercellular Matrix System or ICM. Its mechanism of action is very diverse and also very complex in each case; but it is very interesting to note that its intervention in reproductive processes is of paramount interest. Integrins promote the penetration of the head of spermatozoon into the oocyte, cause the secretion of nutrient substances in the tubal mucosa and finally determine the formation of the "implantation window" in the endometrium. Further penetration of egg in the decidua and the formation of the placental trophoblast originate from the action of integrins. In certain pathologic situations as ectopic pregnancy or endometriosis, integrins play a primordial role. In the treatment of infertility and in the technology of IVF.
Assuntos
Integrinas/fisiologia , Reprodução/fisiologia , Animais , Carcinoma/metabolismo , Carcinoma/secundário , Adesão Celular , Decídua/metabolismo , Implantação do Embrião/fisiologia , Endometriose/metabolismo , Endometriose/patologia , Endométrio/metabolismo , Proteínas da Matriz Extracelular/metabolismo , Tubas Uterinas/fisiologia , Feminino , Fertilização , Fertilização in vitro , Neoplasias dos Genitais Femininos/patologia , Humanos , Infertilidade/terapia , Integrinas/química , Integrinas/classificação , Masculino , Ciclo Menstrual/fisiologia , Camundongos , Neoplasias Peritoneais/metabolismo , Neoplasias Peritoneais/secundário , Gravidez , Gravidez Ectópica/metabolismo , Cabeça do Espermatozoide/química , Cabeça do Espermatozoide/fisiologia , Interações Espermatozoide-Óvulo , Trofoblastos/metabolismoRESUMO
No disponible
Assuntos
Adulto , Idoso , Feminino , Pessoa de Meia-Idade , Humanos , Cuidados para Prolongar a Vida/métodos , Cuidados para Prolongar a Vida/normas , Cuidados para Prolongar a Vida/organização & administração , Qualidade de Vida , Pós-Menopausa , Osteoporose Pós-Menopausa/prevenção & controle , Saúde da Mulher , Serviços de Saúde da Mulher/normas , Serviços de Saúde da Mulher/provisão & distribuição , Cuidados para Prolongar a Vida , Osteoporose/prevenção & controle , Doença de Alzheimer/prevenção & controle , Menopausa , Terapia de Reposição de Estrogênios/métodos , Terapia de Reposição de Estrogênios/normas , Neoplasias/prevenção & controleRESUMO
The author exposes the present concept of metabolic syndrome X, which is a complex of Type II diabetes, obesity, hypertension and vascular problems. This syndrome has been known for many years, but it has been individualized as such only recently. This is due to the huge importance that obesity is reaching in developed countries, especially in the U.S.A. Today this is a very important health problem. In this work, in addition to the description of the syndrome, which is purely an internal medicine issue, its relation to some women-specific problems is also explained, especially to the so-called polycystic ovary.
Assuntos
Diabetes Mellitus Tipo 2/fisiopatologia , Diabetes Mellitus/fisiopatologia , Resistência à Insulina/fisiologia , Obesidade , Diabetes Mellitus/patologia , Feminino , Humanos , Hiperlipidemias/fisiopatologia , Hipertensão/fisiopatologia , Leptina/fisiologia , Menopausa , Isquemia Miocárdica/fisiopatologia , Fenótipo , Síndrome do Ovário Policístico/etiologia , SíndromeRESUMO
This paper summarizes the experience from 78,000 biopsies of the endometrium taken and studied in collaboration with Dr. Francisco Nogales from 1944 to 1982. This is one of the biggest series existing on this matter and its commentary comprises all the changes in our idea of endometrial biopsy which have taken place in this long period of time.
Assuntos
Endométrio/patologia , Biópsia , Feminino , Humanos , Imuno-Histoquímica , Infertilidade Feminina/etiologia , Infertilidade Feminina/patologia , Doenças Uterinas/diagnósticoRESUMO
Mifepristone (RU 486) is a synthetic steroid obtained by Bailieu in the year 1982. Initially it was used as a abortifacient drug and also as "afterday pill". In this sense it was ethically unacceptable. In France and even in the USA it was banned and the FDA had not given its approval. But in the late five years other uses of this substance were discovered, some of the are very valuable. In this sense, now we are using at new, and it is each practitioner who must decide on the reliability of its indication.
