Correlación de la morfología de la glenoides y la cobertura del acromion con rupturas de manguito rotador / Correlation of glenoid morphology and acromial coverage with rotator cuff tears

Introducción El objetivo de este estudio fue determinar si existen diferencias en el ángulo crítico del hombro medido por resonancia magnética en pacientes con ruptura de manguito rotador en comparación con pacientes sanos, así mismo, determinar la fiabilidad intraobservador del ángulo crítico del hombro. Se midieron diferentes variables en la resonancia magnética las cuales incluían: la extensión lateral del acromion, la altura acromial, la versión de la glenoides, el ángulo lateral del acromion y la inclinación glenoidea. Materiales y métodos Se evaluaron dos grupos de pacientes, el grupo control con un total de 16 pacientes y el grupo con ruptura de manguito rotador con 15 pacientes. Se midió en resonancia magnética el ángulo crítico del hombro, inclinación glenoidea, versión de la glenoides, altura acromial, extensión lateral del acromion y el ángulo lateral del acromion. Se utilizó la prueba T de student para comparación de medias y el coeficiente de correlación de Pearson para la asociación entre variables. Así mismo se utilizó el coeficiente de correlación intraclase para la valoración de la fiabilidad intraobservador. Resultados Se obtuvo un resultado de 0.961 en el coeficiente de correlación intraclase para la fiabilidad intraobservador del ángulo crítico del hombro. En la comparación de medias para el ángulo crítico del hombro entre el grupo control y el grupo con ruptura de manguito rotador se obtuvo un resultado de 32.3°(3.6) vs 35.01°(2.4) con una diferencia estadisticamente significativa(p=0.02). De igual manera se obtuvieron diferencias significativas en la inclinación glenoidea y la versión de la glenoides en ambos grupos (81.56°DE 4.04 vs 77.11° DE 3.84; p=0.004) y (-4.47° DE 4.56 vs -1.58°DE 3.94; p=0.04). Discusión Existen diferencias significativas en la medición del ángulo crítico del hombro medido por resonancia magnética en pacientes sanos y pacientes con ruptura de manguito rotador.

Background The purpose of this study was to determine if there is a difference between the critical shoulder angle measured by MRI in patients with rotator cuff tear and healthy patients, also to evaluate the intraobserver reliability in this measure. Other variables were included as well, lateral acromial extension, acromial height, glenoid version, glenoid inclination and lateral acromial angle. Materials and methods Two groups were evaluated, the control group consisted in a total of 16 patients and the group with rotator cuff tear consisted of 15 patients. The critical shoulder angle, glenoid inclination, glenoid version, acromial height, lateral acromial extension and lateral acromial angle were measured on MRI. A student T test was used for comparison of means between both groups, Pearson correlation coefficient was used for evaluating the association between variables. The intraobserver reliability was evaluated using the intraclass correlation coefficient. Results A result of 0.961 was obtained for the intraobserver reliability using the intraclass correlation coefficient for the critical shoulder angle. For the comparison of means of the critical shoulder angle in the control group and the rotator cuff tear group a result of 32.3° (3.6) vs. 35.01° (2.4) was obtained with a statistically significant difference of p=0.02. Likewise, statistically significant differences were obtained in the glenoid inclination and glenoid version in both groups (81.56° SD 4.04 vs 77.11° SD 3.84; p=0.004) and (−4.47° SD 4.56 vs −1.58° SD 3.94; p=0.04). Discussion Critical shoulder angle measured by MRI is statistically significant different in control group and in rotator cuff tear group.

Prevalence of latent and overt polyautoimmunity in autoimmune thyroid disease: A systematic review and meta-analysis.

BACKGROUND: Thyroid autoimmunity is the most frequent condition involved in polyautoimmunity (PolyA). However, the frequency of latent and overt PolyA in patients with autoimmune thyroid disease (AITD) as the index condition is unknown. Therefore, the purpose of this study was to determine the prevalence of these types of PolyA in patients with AITD as the index condition. METHODS: This study adhered to the relevant sections of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guideline. Searches through MEDLINE, Embase and LILACS were done to find articles in Spanish and English. Relevant vocabulary terms and key terms related to AITD and other autoimmune diseases were used. Two investigators independently screened the eligible studies, extracted data and assessed the quality and risk of bias. Fixed and random effect models were used accordingly. Cluster analysis was used to determine similarities among diseases in the articles included (based on Jaccard index). RESULTS: A total of 56 articles fulfilled the inclusion criteria. Of these, 25 were case-controls, 17 were cohorts, and 14 were cross-sectional studies. These studies included a total of 47 509 patients. Female was the predominant gender and included 38 950 patients (81.23%, 95% CI: 80.85-81.60). Graves' disease (GD) was the most common type of thyroid autoimmunity (69.16%, 95% CI: 68.23-70.07). Globally, overt PolyA was found in 13.46% of the patients with AITD. This type of PolyA was represented mainly by type 1 diabetes and autoimmune gastritis. Latent PolyA was presented in 17.45% of the patients, and anti-proinsulin, anti-parietal cells and dsDNA antibodies were the most common. HT had the highest frequency of overt PolyA in Europe (15.60%, 95% CI: 14.72-16.53), whereas latent PolyA was most common in patients with GD in Asia (21.03%, 95% CI: 17.76-24.71). Overt and latent PolyA were associated with gastrointestinal and endocrinological ADs in most of cases and clustered with rheumatological, dermatological and neurological ADs. CONCLUSIONS: Latent and overt PolyA are common in patients with AITD. These results provide insightful information for early diagnosis and management of concurrent ADs in patients with AITD. Aggregation of ADs in different clusters may help to define different phenotypes associated with thyroid autoimmunity that are critically relevant in clinical settings.

Phylogenetic evidence that both ancient vicariance and dispersal have contributed to the biogeographic patterns of anchialine cave shrimps.

Cave shrimps from the genera Typhlatya, Stygiocaris and Typhlopatsa (Atyidae) are restricted to specialised coastal subterranean habitats or nearby freshwaters and have a highly disconnected distribution (Eastern Pacific, Caribbean, Atlantic, Mediterranean, Madagascar, Australia). The combination of a wide distribution and a limited dispersal potential suggests a large-scale process has generated this geographic pattern. Tectonic plates that fragment ancestral ranges (vicariance) has often been assumed to cause this process, with the biota as passive passengers on continental blocks. The ancestors of these cave shrimps are believed to have inhabited the ancient Tethys Sea, with three particular geological events hypothesised to have led to their isolation and divergence; (1) the opening of the Atlantic Ocean, (2) the breakup of Gondwana, and (3) the closure of the Tethys Seaway. We test the relative contribution of vicariance and dispersal in the evolutionary history of this group using mitochondrial genomes to reconstruct phylogenetic and biogeographic scenarios with fossil-based calibrations. Given that the Australia/Madagascar shrimp divergence postdates the Gondwanan breakup, our results suggest both vicariance (the Atlantic opening) and dispersal. The Tethys closure appears not to have been influential, however we hypothesise that changing marine currents had an important early influence on their biogeography.