Assuntos
Encéfalo/metabolismo , Radioisótopos de Carbono , Compostos Radiofarmacêuticos/farmacocinética , Receptores de GABA/metabolismo , Ácido gama-Aminobutírico/análogos & derivados , Animais , Ligação Competitiva , Proteínas Sanguíneas/metabolismo , Encéfalo/diagnóstico por imagem , Feminino , Humanos , Camundongos , Ligação Proteica , Compostos Radiofarmacêuticos/sangue , Compostos Radiofarmacêuticos/metabolismo , Tomografia Computadorizada de Emissão , Ácido gama-Aminobutírico/sangue , Ácido gama-Aminobutírico/metabolismo , Ácido gama-Aminobutírico/farmacocinéticaRESUMO
Coagulation of medial and lateral parts of the lateral hypothalamic area increases latency of responses and decreases respiration, arterial blood pressure and heart rate responses to stimulation of the hypothalamic ventromedial nucleus. Coagulation of the perifornical region of the lateral hypothalamus completely eliminates the above autonomic responses. A new rigid integration which is characterized with the increased number of correlated relations between separate components of somato-autonomic responses, was postulated after correlation analysis of somato-autonomic parameters during stimulation of hypothalamic ventromedial nucleus in animals with lateral hypothalamic lesions. The data suggest that somato-autonomic responses to stimulation of negative emotion sites of the hypothalamus are mediated by those brain structures which are under ascending excitatory influences of the lateral hypothalamus.
