Cytotoxicity of novel hybrid composite materials for making bone fracture plates.

Bone fracture plates are usually made from steel or titanium, which are much stiffer than cortical bone. This may cause bone 'stress shielding' (i.e. bone resorption leading to plate loosening) and delayed fracture healing (i.e. fracture motion is less than needed to stimulate callus formation at the fracture). Thus, the authors previously designed, fabricated, and mechanically tested novel 'hybrid' composites made from inorganic and organic materials as potential bone fracture plates that are more flexible to reduce these negative effects. This is the first study to measure the cytotoxicity of these composites via the survival of rat cells. Cubes of carbon fiber/flax fiber/epoxy and glass fiber/flax fiber/epoxy had better cell survival vs. Kevlar fiber/flax fiber/epoxy (57% and 58% vs. 50%). Layers and powders made of carbon fiber/epoxy and glass fiber/epoxy had higher cell survival than Kevlar fiber/epoxy (96%-100% and 100% vs. 39%-90%). The presence of flax fibers usually decreased cell survival. Thus, carbon and glass fiber composites (with or without flax fibers), but not Kevlar fiber composites (with or without flax fibers), may potentially be used for bone fracture plates.

Biomechanical effects of different loads and constraints on finite element modeling of the humerus.

Currently, there is no established finite element (FE) method to apply physiologically realistic loads and constraints to the humerus. This FE study showed that 2 'simple' methods involving direct head loads, no head constraints, and rigid elbow or mid-length constraints created excessive stresses and bending. However, 2 'intermediate' methods involving direct head loads, but flexible head and elbow constraints, produced lower stresses and bending. Also, 2 'complex' methods involving muscles to generate head loads, plus flexible head and elbow constraints, generated the lowest stresses and moderate bending. This has implications for FE modeling research on intact and implanted humeri.

Effect of Injection Parameters on the MRI and Dielectric Properties of Condensation-Cured Silicone.

Phantoms with tissue-mimicking properties play a crucial role in the calibration of medical imaging modalities, including Magnetic Resonance Imaging (MRI). Among these phantoms, silicone-based ones are widely used due to their long-term stability in MR imaging. Most of these phantoms are manufactured using traditional pour-mold techniques which often result in the production of air bubbles that can damage the phantom. This research investigates the feasibility of utilizing extrusion techniques to fabricate silicone phantoms and explores the effects of extrusion parameters including plunger speed and nozzle diameter on void content, T1 and T2 relaxation times, and dielectric properties. A custom double-syringe silicone extrusion apparatus was developed to prepare the silicone samples. The void content, relaxometry, and dielectric properties of extruded samples were measured and compared with traditional poured samples. The results show that extrusion parameters can affect the void content of the silicone samples. The presence of voids in the samples resulted in lower T1 values, indicating an inverse relationship between void content and relaxometry. This study demonstrates the potential of extrusion techniques for manufacturing silicone phantoms with reduced air bubble formation and provides valuable insights into the relationship between extrusion parameters and phantom properties.

Experimental and numerical investigation of 3D-Printed bone plates under four-point bending load utilizing machine learning techniques.

The fused deposition modeling (FDM) technique is widely used to produce components for various applications and has the potential to revolutionize orthopedic research through the production of custom-fit and readily available biomedical implants. The properties of FDM-produced implants are significantly influenced by processing parameters, with layer thickness being a crucial parameter. This study investigated the effect of layer thickness on the flexural properties of Polylactic Acid (PLA) bone plate implants produced by the FDM technique. Experimental results showed that the flexural strength is inversely proportional to the layer thickness due to the variation of voids in the specimens. A 3D finite element (FE) model was developed using Abaqus/Explicit software by incorporating the Gurson-Tvergaard (GT) porous plasticity model to predict the elastoplastic and damage behavior of specimens with different layer thicknesses. The characterization of the elastoplastic and GT parameters was done using a tensile test and by the calibration of a machine learning algorithm. It was shown that the FE model was able to predict the flexural behavior of 3D-printed solid plates with a maximum error of 6.13% in the maximum load. The optimal layer height was found to be 0.1 mm, providing both high flexural strength and adequate bending stiffness.

Computational prediction of the long-term behavior of the femoral density after THR using the Silent Hip stem.

Aseptic loosening due to the progressive periprosthetic bone resorption following total hip replacement is a crucial concern, that causes complications and failure of the arthroplasty surgery. The mismatch in stiffness between the hip implant and the surrounding femoral bone is one of the key factors leading to bone density resorption. This paper aimed to investigate the long-term response of the femoral bone after THR using the Silent Hip stem. For this purpose, a validated thermodynamic-based computational model was used to compute the change in bone density before and after THR. This model incorporated essential factors involved in bone remodeling process, such as mechanical loading, and biochemical affinities. The results of the numerical simulations using 3D finite element analysis were analyzed in five zones of interest qualitatively and quantitatively. Bone density predictions showed notable bone resorption in cervical areas, specifically in zone 1 and zone 5 of -18.7% and -14%, respectively. Conversely, bone formation was observed in the greater trochanter area (zone 2) of +25%. Stress shielding seemed to occur at cervical area due to the reduction in the mechanical loading in this region. Based on the quantitative analysis of the bone density distribution throughout the femoral bone, it appears that the Silent Hip stem achieved less bone resorption compared to conventional hip stem designs reported in the literature, which could be used for active patients.

Biomechanical optimization of the far cortical locking technique for early healing of distal femur fractures.

This finite element study optimized far cortical locking (FCL) technology for early callus formation in distal femur fracture fixation with a 9-hole plate using FCL screws proximal to, and standard locking screws distal to, the fracture. Analyses were done for 120 possible FCL screw configurations by varying FCL screw distribution and number. A hip joint force of 700 N (i.e. 100% x body weight) was used, which corresponds to a typical 140 N "toe-touch" foot-to-ground force (i.e. 20% x body weight) suggested to patients immediately after surgery. Increased FCL screw distribution (i.e. shorter plate working length) caused a decrease at the medial side and an increase at the lateral side of the axial interfragmentary motion (AIM), mildly affected shaft and condylar cortex Von Mises max stress (σMAX), increased plate σMAX, and decreased shaft FCL screw and condylar locking screw σMAX. Increased FCL screw number decreased AIM and σMAX on the shaft cortex, condylar cortex, plate, and FCL screws, but not condylar screws. The optimal FCL screw configuration had 3 FCL screws in plate holes #1, 5, and 6 (proximal to distal) for optimal AIM of 0.2 - 1 mm and reduce shear fracture motion, thereby encouraging early callus formation.

Quasi-static analysis of hip cement spacers.

The use of temporary hip prosthesis made of orthopedic cement (spacer) in conjunction with antibiotics became a widespread method used for treating prosthetic infections despite the fact that this method makes bone cement (PMMA) more fragile. The necessity to incorporate reinforcement is therefore crucial to strengthen the bone cement. In this study, a validated Finite Element Modelling (FEM) was used to analyze the behavior of spacers. This FEM model uses a non-linear dynamic explicit integration to simulate the mechanical behavior of the spacer under quasi-static loading. In addition to this FEM, Extended Finite Element Method (XFEM) was also used to investigate the fracture behavior of the spacers reinforced with titanium, ceramic and stainless-steel spacer stems. The effect of the material on the performance of the reinforced spacers was also analyzed. The results showed that numerical modelling based on explicit finite element using ABAQUS/Explicit is an effective method to predict the different spacers' mechanical behavior. The simulated crack initiation and propagation were in a good agreement with experimental observations. The FEM models developed in this study can help mechanical designers and engineers to improve the prostheses' quality and durability.

Biomechanical design using in-vitro finite element modeling of distal femur fracture plates made from semi-rigid materials versus traditional metals for post-operative toe-touch weight-bearing.

This proof-of-concept study designs distal femur fracture plates from semi-rigid materials vs. traditional metals for toe-touch weight-bearing recommended to patients immediately after surgery. The two-fold goal was to (a) reduce stress shielding (SS) by increasing cortical bone stress thereby reducing the risk of bone absorption and plate loosening, and (b) reduce delayed healing (DH) via early callus formation by optimizing axial interfragmentary motion (AIM). Finite element analysis was used to design semi-rigid plates whose elastic moduli E ensured plates permitted AIM of 0.2 - 1 mm for early callus formation. A low hip joint force of 700 N (i.e. 100% x body weight) was applied, which corresponds to a typical 140 N toe-touch foot-to-ground force (i.e. 20% x body weight) recommended to patients after surgery. Analysis was done using 2 screw materials (steel or titanium) and types (locked or non-locked). Steel and titanium plates were also analyzed. Semi-rigid plates (vs. metal plates) had lower overall femur/plate construct stiffnesses of 508 - 1482 N/mm, higher cortical bone stresses under the plate by 2.02x - 3.27x thereby reducing SS, and lower E values of 414 - 2302 MPa to permit AIM of 0.2 - 1 mm thereby reducing DH.

Biomechanical analysis of transverse acetabular fracture fixation in the elderly via the posterior versus the anterior approach with and without a total hip arthroplasty.

This study provides the first biomechanical comparison of the fixation constructs that can be created to treat transverse acetabular fractures when using the "gold-standard" posterior versus the anterior approach with and without a total hip arthroplasty in the elderly. Synthetic hemipelvises partially simulating osteoporosis (n = 24) were osteotomized to create a transverse acetabular fracture and then repaired using plates/screws, lag screws, and total hip arthroplasty acetabular components in one of four ways: posterior approach (n = 6), posterior approach plus a total hip arthroplasty acetabular component (n = 6), anterior approach (n = 6), and anterior approach plus a total hip arthroplasty acetabular component (n = 6). All specimens were biomechanically tested. No differences existed between groups for stiffness (range, 324.6-387.3 N/mm, p = 0.629), clinical failure load at 5 mm of femoral head displacement (range, 1630.1-2203.9 N, p = 0.072), or interfragmentary gapping (range, 0.67-1.33 mm, p = 0.359). Adding a total hip arthroplasty acetabular component increased ultimate mechanical failure load for posterior (2904.4 vs. 3652.3 N, p = 0.005) and anterior (3204.9 vs. 4396.0 N, p = 0.000) approaches. Adding a total hip arthroplasty acetabular component also substantially reduced interfragmentary sliding for posterior (3.08 vs. 0.50 mm, p = 0.002) and anterior (2.17 vs. 0.29 mm, p = 0.024) approaches. Consequently, the anterior approach with a total hip arthroplasty may provide the best biomechanical stability for elderly patients, since this fixation group had the highest mechanical failure load and least interfragmentary sliding, while providing equivalent stiffness, clinical failure load, and gapping compared to other surgical options.

Biomechanical Response under Stress-Controlled Tension-Tension Fatigue of a Novel Carbon Fiber/Epoxy Intramedullary Nail for Femur Fractures.

Metallic intramedullary nails are the "gold standard" implant for repairing femur shaft fractures. However, their rigidity may eliminate axial micromotion at the fracture (causing delayed healing) and they may carry too much load relative to the femur (causing "stress shielding"). Consequently, some researchers have proposed fiber-reinforced composite nails, but only one evaluated cyclic fatigue performance. Therefore, this study assessed the cyclic fatigue response of a carbon fiber/epoxy nail with a novel ply stacking sequence of [02/-45/452/-45/0/-45/452/-452/452/-45/902] previously developed by the present authors. Nails were cyclically loaded in tension-tension at 5 Hz with a stress ratio of R=0.1 from 30% - 85% of the material's ultimate tensile strength (UTS). Thermographic stress analysis, rather than conventional fatigue testing, was used to obtain high cycle fatigue strength (HCFS), below which the nail can be cyclically loaded indefinitely without damage. Also, the mechanical test machine's built-in load cell and an extensometer were used to create stress-strain curves, from which the change in static EO and dynamic E* moduli were obtained. Results showed that HCFS was 70.3% of UTS (or about 283 MPa), while EO and E* remained at 42 GPa without any dRegradation during testing. The current nail shows potential for clinical use.

In- vitro evaluation of the bioactivity and the biocompatibility of a novel coated UHMWPE biomaterial for biomedical applications.

Ultra-High Molecular Weight Polyethylene (UHMWPE) is the gold standard biomaterial used as a bearing surface in total joint replacement surgeries. However, osteolysis and subsequent implant failure as a result of the production of wear debris may occur at the contacting surfaces. One potential solution to overcome this problem is to strengthen the surface of UHMWPE which can be achieved by adding a thin coating layer made of Polyamide. In this article, a combination of biological and biochemical tests, including cell viability, antibacterial activity (using Escherichia coli and Staphylococcus aureus), and wound healing assays were performed to assess the bioactivity and the biocompatibility of the coated specimens. Additional tests, such as simulated body fluid absorption, Alizarin Red Staining, Scanning Electron Microscopy, Energy-dispersive X-ray spectroscopy, and Fourier-transform infrared spectroscopy techniques were conducted to evaluate the moisture uptake, osteogenic activity, and the morphology of the coated samples. The antibacterial activity test results after 24 h incubation showed that the nylon-coated UHMWPE has significantly higher antibacterial activity compared to the uncoated UHMWPE. The results of wound closure showed that nylon-coated UHMWPE promotes more wound healing compared to the uncoated material that exhibits a similar percentage of wound closure as the control. This is the first study to demonstrate the superiority of the proposed coated biomaterial for wound healing applications with improved antibacterial capabilities.

Mechanical characterization of the static and fatigue compressive properties of a new glass/flax/epoxy composite material using digital image correlation, thermographic stress analysis, and conventional mechanical testing.

This study characterized the static and fatigue compressive properties of a new hybrid composite material made of synthetic and natural fibers with an epoxy matrix. The glass/flax/epoxy composite material was manufactured as a "sandwich structure" with a Type A configuration (i.e. [0G2/0F12/0G2] using unidirectional glass (G) and flax (F) fibers) and Type B configuration (i.e. [0G2/±45F12/0G2] using unidirectional glass (G) and ±45° oblique flax (F) fibers). Digital image correlation was used to obtain the static properties of compressive elastic modulus (Type A, 24.4 GPa; Type B, 14.7 GPa), ultimate compressive strength (Type A, 261.7 MPa; Type B, 231.9 MPa), and Poisson's ratio (Type A, 0.37; Type B, 0.58). Thermographic stress analysis was used to measure a high cycle fatigue strength (HCFS) of 53% (Type A and B) of ultimate compressive strength. Conventional experimental fatigue methods (i.e. stress vs. number of cycles to failure) yielded a HCFS of 56-61% (Type A) and 51-56% (Type B), as well as almost constant dynamic compressive moduli of 15 GPa (Type A) and 10 GPa (Type B) over the entire loading regime. This new composite material may have various potential applications, such as aerospace, automotive, biomechanics, sports, etc., based on the compressive properties measured.

Rotating hinge knee causes lower bone-implant interface stress compared to constrained condylar knee replacement.

PURPOSE: To compare the stresses at bone-arthroplasty interface of constrained and semi-constrained knee prostheses, using the finite element (FE) method as a predictor of the survivorship of the implants. METHODS: Three-dimensional FE models of the knee implanted with rotating hinge (RHK) and legacy constrained condylar (LCCK) prostheses were generated to study the loads and stresses for two situations: medial- and lateral collateral ligament deficiencies in full extension. RESULTS: On average, the shear stress developed at bone-implant interface dropped from 16.9 to 13.7 MPa (18.9%), and the interface von Mises stress lowered from 37.6 to 30.2 MPa (19.6%) in RHK compared to those in LCCK prostheses. RHK design also resulted in a more uniform stress distribution at the interfaces in both femur and tibia. The average polyethylene liner stress dropped from 9.6 to 2.6 MPa (a 72.7% decrease) in RHK design when compared to that in LCCK design. CONCLUSION: The more uniform interface stress suggests fewer density changes at the periprosthetic regions due to bone remodelling. Moreover, the lower polyethylene stresses are likely to reduce wear and damage. These findings reveal that the RHK design may have more favorable mechanical features compared to LCCK design in full extension boundary conditions, implying a potentially better survivorship. However, the findings should be interpreted cautiously as other configurations were not investigated.

Biomechanical Analysis Using FEA and Experiments of Metal Plate and Bone Strut Repair of a Femur Midshaft Segmental Defect.

This investigation assessed the biomechanical performance of the metal plate and bone strut technique for fixing recalcitrant nonunions of femur midshaft segmental defects, which has not been systematically done before. A finite element (FE) model was developed and then validated by experiments with the femur in 15 deg of adduction at a subclinical hip force of 1 kN. Then, FE analysis was done with the femur in 15 deg of adduction at a hip force of 3 kN representing about 4 x body weight for a 75 kg person to examine clinically relevant cases, such as an intact femur plus 8 different combinations of a lateral metal plate of fixed length, a medial bone strut of varying length, and varying numbers and locations of screws to secure the plate and strut around a midshaft defect. Using the traditional "high stiffness" femur-implant construct criterion, the repair technique using both a lateral plate and a medial strut fixed with the maximum possible number of screws would be the most desirable since it had the highest stiffness (1948 N/mm); moreover, this produced a peak femur cortical Von Mises stress (92 MPa) which was below the ultimate tensile strength of cortical bone. Conversely, using the more modern "low stiffness" femur-implant construct criterion, the repair technique using only a lateral plate but no medial strut provided the lowest stiffness (606 N/mm), which could potentially permit more in-line interfragmentary motion (i.e., perpendicular to the fracture gap, but in the direction of the femur shaft long axis) to enhance callus formation for secondary-type fracture healing; however, this also generated a peak femur cortical Von Mises stress (171 MPa) which was above the ultimate tensile strength of cortical bone.

Biomechanical Measurement Error Can Be Caused by Fujifilm Thickness: A Theoretical, Experimental, and Computational Analysis.

This is the first study to quantify the measurement error due to the physical thickness of Fujifilm for several material combinations relevant to orthopaedics. Theoretical and experimental analyses were conducted for cylinder-on-flat indentation over a series of forces (750 and 3000 N), cylinder diameters (0 to 80 mm), and material combinations (metal-on-metal, MOM; metal-on-polymer, MOP; metal-on-bone, MOB). For the scenario without Fujifilm, classic Hertzian theory predicted the true line-type contact width as WO = {(8FDcyl)/(πLcyl)[(1 - νcyl2)/Ecyl + (1 - νflat2)/Eflat]}1/2, where F is compressive force, Dcyl is cylinder diameter, Lcyl is cylinder length, νcyl and νflat are cylinder and flat Poisson's ratios, and Ecyl and Eflat are cylinder and flat elastic moduli. For the scenario with Fujifilm, experimental measurements resulted in contact widths of WF = 0.1778 × F0.2273 × D0.2936 for MOM tests, WF = 0.0449 × F0.4664 × D0.4201 for MOP tests, and WF = 0.1647 × F0.2397 × D0.3394 for MOB tests, where F is compressive force and D is cylinder diameter. Fujifilm thickness error ratio WF /WO showed a nonlinear decrease versus cylinder diameter, whilst error graphs shifted down as force increased. Computational finite element analysis for several test cases agreed with theoretical and experimental data, respectively, to within 3.3% and 1.4%. Despite its wide use, Fujifilm's measurement errors must be kept in mind when employed in orthopaedic biomechanics research.

Biomechanical analysis using FEA and experiments of a standard plate method versus three cable methods for fixing acetabular fractures with simultaneous THA.

Acetabular fractures potentially account for up to half of all pelvic fractures, while pelvic fractures potentially account for over one-tenth of all human bone fractures. This is the first biomechanical study to assess acetabular fracture fixation using plates versus cables in the presence of a total hip arthroplasty, as done for the elderly. In Phase 1, finite element (FE) models compared a standard plate method versus 3 cable methods for repairing an acetabular fracture (type: anterior column plus posterior hemi-transverse) subjected to a physiological-type compressive load of 2207N representing 3 x body weight for a 75kg person during walking. FE stress maps were compared to choose the most mechanically stable cable method, i.e. lowest peak bone stress. In Phase 2, mechanical tests were then done in artificial hemipelvises to compare the standard plate method versus the optimal cable method selected from Phase 1. FE analysis results showed peak bone stresses of 255MPa (Plate method), 205MPa (Mears cable method), 250MPa (Kang cable method), and 181MPa (Mouhsine cable method). Mechanical tests then showed that the Plate method versus the Mouhsine cable method selected from Phase 1 had higher stiffness (662versus 385N/mm, p=0.001), strength (3210versus 2060N, p=0.009), and failure energy (8.8versus 6.2J, p=0.002), whilst they were statistically equivalent for interfragmentary sliding (p≥0.179) and interfragmentary gapping (p≥0.08). The Plate method had superior mechanical properties, but the Mouhsine cable method may be a reasonable alternative if osteoporosis prevents good screw thread interdigitation during plating.

Investigation of the mechanical properties and failure modes of hybrid natural fiber composites for potential bone fracture fixation plates.

The purpose of this study is to investigate the mechanical feasibility of a hybrid Glass/Flax/Epoxy composite material for bone fracture fixation such as fracture plates. These hybrid composite plates have a sandwich structure in which the outer layers are made of Glass/Epoxy and the core from Flax/Epoxy. This configuration resulted in a unique structure compared to prior composites proposed for similar clinical applications. In order to evaluate the mechanical properties of this hybrid composite, uniaxial tension, compression, three-point bending and Rockwell Hardness tests were conducted. In addition, water absorption tests were performed to investigate the rate of water absorption for the specimens. This study confirms that the proposed hybrid composite plates are significantly more flexible axially compared to conventional metallic plates. Furthermore, they have considerably higher ultimate strength in tension, compression and flexion. Such high strength will ensure good stability of bone-implant construct at the fracture site, immobilize adjacent bone fragments and carry clinical-type forces experienced during daily normal activities. Moreover, this sandwich structure with stronger and stiffer face sheets and more flexible core can result in a higher stiffness and strength in bending compared to tension and compression. These qualities make the proposed hybrid composite an ideal candidate for the design of an optimized fracture fixation system with much closer mechanical properties to human cortical bone.

Biomechanical optimization of the angle and position for surgical implantation of a straight short stem hip implant.

Conservative hip implants preserve healthy bone for revision surgeries and improve physiological loading; however, they have little supporting biomechanical data with respect to their 3D orientation during implantation. This study endeavored to determine the optimal 3D orientation of a straight short stem hip implant within the proximal femur that would yield a stress distribution most similar to an intact femur. Synthetic femurs were implanted with a stem in one of seven maximum angles or positions and axially loaded, with resultant strain values used to validate a finite element model. Design of experiments was used to analyze the range of potential implant orientations under three gait cycle loading conditions. A global optimal orientation of 9.14° valgus, 2.49° anteversion, 0.48mm posterior position, and 0.23mm inferior position was found to yield stress distributions most similar to the intact femur across the gait cycle range. In general, it was determined that the valgus orientation was optimal throughout the gait cycle, consistently exhibiting a stress distribution more similar to that of the intact femur. Minimal levels of anterior/posterior and inferior positioning were seen to be beneficial in achieving more physiological stresses in specific regions of interest within the proximal femur, while the anteverted orientation was only beneficial in loading under flexion. Overall, orthopaedic surgeons should aim to implant straight short stem hip implants in valgus up to 10°, with an otherwise neutral position and version, unless some degree of deviation would be beneficial for a patient-specific reason. This work has implications for the best surgical placement of straight short stem hip implants to yield maximal biomechanical stability.

Biomechanical analysis of the cephalomedullary nail versus the trochanteric stabilizing plate for unstable intertrochanteric femur fractures.

Unstable intertrochanteric fractures are commonly treated with a cephalomedullary nail due to high failure rates with a sliding hip screw. The Omega3 Trochanteric Stabilizing Plate is a relatively new device that functions like a modified sliding hip screw with a proximal extension; however, its mechanical properties have not been evaluated. This study biomechanically compared a cephalomedullary nail, that is, Gamma3 Nail against the Omega3 plate. Unstable intertrochanteric fractures were created in 24 artificial femurs. Experimental groups were as follows: Nail (i.e. Gamma3 Nail) (n = 8), Plate A (i.e. Omega3 plate with four distal non-locking screws and no proximal locking screws) (n = 8), Plate B (i.e. Plate A plus five proximal locking screws) (n = 8), Plate C (i.e. Omega3 plate with three distal locking screws and no proximal locking screws) (n = 8), and Plate D (i.e. Plate C plus five proximal locking screws) (n = 8). All specimens were stiffness tested, while the Nail and Plate D groups were also strength tested. For lateral bending, Plate B was less stiff than the Nail (p = 0.001) and Plate A (p = 0.009). For torsion, Plate A was less stiff than Plate D (p = 0.020). For axial compression, the Nail was less stiff than Plate A (p = 0.036) and Plate B (p = 0.008). Axial strength for the Nail (5014 ± 308 N) was 66% higher than the Plate D construct (2940 ± 411 N) (p < 0.001). All Nails failed by partial or complete cutout through the femoral head and neck, but Plate D failed by varus collapse and deformation of the lag screw. When the cephalomedullary nail is clinically contra-indicated, this study supports the use of the Omega3 plate, since it had similar stiffness in three test modes to the Gamma3 Nail, but had lower strength. Stability of Omega3 plate constructs was not improved with locked fixation proximally or distally.

Long-term response of femoral density to hip implant and bone fracture plate: Computational study using a mechano-biochemical model.

Although bone fracture plates can provide appropriate stability at the fracture site and lead to early patient mobilization, they significantly change the loading pattern in the bone after union (Stress shielding). This phenomenon results in a bone density decrease, which may cause premature failure of the implant. This paper presents the first study that quantifies the long-term response of femoral density to hip implantation and plating (lateral and anterior plating) using a mechano-biochemical model which considers the coupling effect between mechanical loading and biochemical affinities as stimuli for bone remodeling. The results showed that the regions directly beneath the plate experienced severe bone loss (i.e. up to ∼ -70%). However, some level of bone formation was observed in the vicinity of the most proximal and distal screw holes in both lateral and anterior plated femurs (i.e. up to ∼ +110%). The bone under the plate was divided into six zones. With respect to bone remodeling response, the findings revealed that anterior plating was not superior to lateral plating since the maximum and average bone losses among the zones in the anterior plated femur (i.e. -36% and -24%, respectively) were approximately the same as their corresponding values in the lateral plated femur (i.e. -38% and -24%, respectively).