[Pancreatic adenomatous hyperplasia and sudden infant death]. / Hyperplasie adénomateuse du pancréas et mort subite du nourrisson.

We report the observation of a sudden infant death in which autopsy revealed a focal pancreatic lesion called adenomatous hyperplasia. Histopathological and immunohistochemical characteristics of this lesion are detailed. Adenomatous hyperplasia and endocrine cell dysplasia are the two pancreatic lesions responsible for hyperinsulinemic hypoglycemia in infants, with a possible fatal evolution. An organic pancreatic lesion is exceptionally reported in observations of sudden infant death. These observations and ours point out the necessity of a meticulous post-mortem examination of the pancreas in sudden infant death.

[Value of fast indirect immunofluorescence diagnosis of respiratory viruses]. / Intérêt de la détection rapide par immunofluorescence indirecte des virus à tropisme respiratoire.

Four hundred and three nasopharyngeal aspirates from hospitalized children have been analysed for RSV, influenza A and B, parainfluenza 3, adenovirus, with Monofluor Kits Diagnostics Pasteur. One hundred and seventeen positive samples were found, RSV: 69, influenza A: 17, influenza B: 12, parainfluenza 3: 2 and adenovirus: 17. Rapid diagnosis of viral diseases allows to decrease the incidence of nosocomial infections, to watch over infants carrying RSV who might develop severe bronchiolitis. This technique combined with anatomic examination showed that sudden death occurred, in 7 of 15 infants, during an acute respiratory infection (RSV: 6).

[Pleuropulmonary colibacillus infection in a 9-year-old boy leading to the diagnosis of Bruton agammaglobulinemia]. / Infection pleuro-pulmonaire à colibacille chez un garçon de neuf ans, conduisant au diagnostic d'agammaglobulinémie de Bruton.

A nine-year-old boy was hospitalized for pneumonia of the left lower lobe. A left pleural effusion developed 48 hours later. The same E. coli strain was recovered from five blood cultures, pleural fluid, and middle ear fluid. Recovery was achieved after two months. Pleural lavage was performed twice daily for the first 15 days and parenteral antimicrobial therapy was given for 45 days. Because E. coli is not usually responsible for ENT or lower respiratory tract infections, an immune deficiency was sought for. The index patient had a twin in whom a history of osteomyelitis at the age of 2 and pneumonia at the age of 8 was found. Recurrent otitis had been a problem in both twins from the age of 14 months. In both twins, immunoglobulin assays led to the diagnosis of Bruton agammaglobulinemia. These two children are now receiving intravenous infusions of human immunoglobulins every three weeks. Bruton agammaglobulinemia is infrequently diagnosed at so late an age.

[Course of ampicillin sensitivity in Haemophilus influenzae responsible for purulent meningitis in children. Therapeutic consequences]. / Evolution de la sensibilité à l'ampicilline des Haemophilus influenzae responsables de méningites purulentes chez l'enfant. Conséquences thérapeutiques.

Bacterial meningitis caused by Haemophilus influenzae observed from 1976 to 1980 (10 cases) are compared with those observed in 1981 (9 cases). From 1976 to 1980, 9 strains (90%) are ampicillin-sensitive. In 1981, 5 strains (55,5%) are ampicillin-sensitive and 4 strains (45,5%) are ampicillin-resistant and betalactamase positive. These 9 strains are serotype b. Therefore, since 1981, initial treatment of bacterial meningitis in infancy is a new cephalosporin, in this study is cefotaxime.

[Late lymphedema in Turner's syndrome]. / Lymphoedeme tardif dans le syndrome de Turner.

Two cases of delayed unilateral lymphedema are reported in children presenting with Turner's syndrome. On this occasion, the frequency of lymphedema in Turner's syndrome and the more general problem of the lymphatic changes in this syndrome are discussed. The importance of isotopic lymphography is emphasized, because of its simplicity, its harmlessness and the good quality of the morphological and cinetic data obtained.