[Epidemiological and clinical profile of chronic venous disease in the hotel-catering sector of the Setif region, Algeria, during the period 2016-2018]. / Profil épidémiologique et clinique de I 'insuffisance veineuse chronique dans le secteur d'hôtellerie-restauration de la région de Sétif-Algérie durant la période 2016-2018.

The purpose of our work is to carry out an epidemiological study among the workers of 18 hotels in the region of Setif, in order to estimate the prevalence of this pathology, to identify the risk factors and to propose prevention recommendations. The study population concerned a total workforce of 628 male-dominated workers, interesting 18 hotels in the region of Setif, whose hotel staff consists of floor staff, kitchen and catering, reception and security reception and maintenance. Workers responded to a pre-established questionnaire to collect socio-demographic and occupational data, reviewing all venous risk factors and functional symptoms. The venous clinical examination of the lower limbs was carried out with reference to the international classification CEAP. Our study found a high prevalence of CVI in the hotel and restaurant sector (62.4%). A significant association of CVI is found with age, female gender, familial inheritance of CVI, overweight and obesity. Floor and kitchen trades were the most concerned with CVI, with prolonged standing posture, heavy loads, among the occupational factors taken into account. The high prevalence of CVI in the hotel and restaurant sector motivate change in the low-profile and discriminatory image of this frequent and chronic condition. Multidisciplinary work is at the heart of integrated care, the occupational physician can contribute to the early detection and prevention of this disease in the workplace.

Comparative enantioselectivity in the sulphoxidation of albendazole in man, dogs and rats.

1. H.p.l.c. analyses were performed to investigate the plasma kinetics of albendazole (ABZ), the sulphoxide (SO.ABZ) and sulphone (SO2ABZ) metabolites, as well as the chirality vs time of SO.ABZ, after oral administration to rats, dogs and man of prochiral sulphide antiparasitic drug ABZ. 2. In all three species the initial plasma concentration ratio of the enantiomers, as soon as SO.ABZ could be detected in plasma, was that of a racemate. 3. Subsequently, the ratio (+)/(-) increased linearly with time, reaching values of 13.1 and 9.3 in man and dogs, respectively, while it decreased to 0.6 in rats. 4. The (+) enantiomer represents 80%, 70% and 41% of the area under the curve of the total SO.ABZ in man, dogs and rats, respectively.