Multidimensional point transform for public health practice.

BACKGROUND: With increases in spatial information and enabling technologies, location-privacy concerns have been on the rise. A commonly proposed solution in public health involves random perturbation, however consideration for individual dimensions (attributes) has been weak. OBJECTIVES: The current study proposes a multidimensional point transform (MPT) that integrates the spatial dimension with other dimensions of interest to comprehensively anonymise data. METHODS: The MPT relies on the availability of a base population, a subset patient dataset, and shared dimensions of interest. Perturbation distance and anonymity thresholds are defined, as are allowable dimensional perturbations. A preliminary implementation is presented using sex, age and location as the three dimensions of interest, with a maximum perturbation distance of 1 kilometre and an anonymity threshold of 20%. A synthesised New York county population is used for testing with 1000 iterations for each of 25, 50, 100, 200 and 400 patient dataset sizes. RESULTS: The MPT consistently yielded a mean perturbation distance of 46 metres with no sex or age perturbation required. Displacement of the spatial mean decreased with patient dataset size and averaged 5.6 metres overall. CONCLUSIONS: The MPT presents a flexible, customisable and adaptive algorithm for perturbing datasets for public health, allowing tweaking and optimisation of the trade-offs for different datasets and purposes. It is not, however, a substitute for secure and ethical conduct, and a public health framework for the appropriate disclosure, use and dissemination of data containing personal identifiable information is required. The MPT presents an important component of such a framework.

A proposed semantic framework for diabetes education content management, customisation and delivery within the M2DM project.

M2DM (multi access services for telematic management of diabetes mellitus, ) is an EU-funded telemedicine project that aims at increasing the quality of diabetes care by improving communication between patients and caregivers. As part of this project, we have undertaken the initial work of describing the necessary requirements (framework) of an advanced educational component for M2DM in accordance with the latest Semantic Web concepts. This paper describes our proposed semantic framework for educational content management, customisation and delivery. A big internet challenge today is to find and push situation and user-specific quality knowledge to users based on their actual individual needs, circumstances and profiles at any given time. We believe that the semantic framework presented in this paper could be a good step towards meeting this challenge. Benefits for users, both developers and end users, of adopting such framework are also discussed. The ideas discussed in this paper could be easily adapted to other similar services besides M2DM and to different health topics besides diabetes mellitus.

A dynamic problem to knowledge linking Semantic Web service based on clinical codes.

Many information needs arise during everyday clinical practice. Problem to knowledge linking aims to answer these needs by providing contextually appropriate medical knowledge in the right place and at the right time. Empirical evidence shows that well-informed physicians and patients are able to make better clinical decisions that positively affect healthcare outcomes. This paper reports on the design and development of a re-usable and flexible Semantic Web problem to knowledge linking service. The service makes use of metadata and clinical codes contextually to link disparate Electronic Patient Record clients to resources in an online medical knowledge service (HealthCyberMap). Clinical codes act as crisp knowledge hooks, providing a reliable common backbone language for communication between Electronic Patient Records and HealthCyberMap. Ideas to improve the service are also discussed. By minimizing irrelevant leads (noise) and reducing the time needed to find relevant information (the right contextually relevant knowledge is linked to real patient data in the Electronic Patient Record), the system is potentially beneficial. The actual success of the system will depend on the quality and granularity of metadata it uses and the topical coverage and quality of resources to which it points.

The use of quality benchmarking in assessing web resources for the dermatology virtual branch library of the National electronic Library for Health (NeLH).

BACKGROUND: In 1998, the U.K. National Health Service Information for Health Strategy proposed the implementation of a National electronic Library for Health to provide clinicians, healthcare managers and planners, patients and the public with easy, round the clock access to high quality, up-to-date electronic information on health and healthcare. The Virtual Branch Libraries are among the most important components of the National electronic Library for Health. They aim at creating online knowledge based communities, each concerned with some specific clinical and other health-related topics. OBJECTIVES: This study is about the envisaged Dermatology Virtual Branch Libraries of the National electronic Library for Health. It aims at selecting suitable dermatology Web resources for inclusion in the forthcoming Virtual Branch Libraries after establishing preliminary quality benchmarking rules for this task. Psoriasis, being a common dermatological condition, has been chosen as a starting point. METHODS: Because quality is a principal concern of the National electronic Library for Health, the study includes a review of the major quality benchmarking systems available today for assessing health-related Web sites. The methodology of developing a quality benchmarking system has been also reviewed. Aided by metasearch Web tools, candidate resources were hand-selected in light of the reviewed benchmarking systems and specific criteria set by the authors. RESULTS: Over 90 professional and patient-oriented Web resources on psoriasis and dermatology in general are suggested for inclusion in the forthcoming Dermatology Virtual Branch Libraries. The idea of an all-in knowledge-hallmarking instrument for the National electronic Library for Health is also proposed based on the reviewed quality benchmarking systems. CONCLUSIONS: Skilled, methodical, organized human reviewing, selection and filtering based on well-defined quality appraisal criteria seems likely to be the key ingredient in the envisaged National electronic Library for Health service. Furthermore, by promoting the application of agreed quality guidelines and codes of ethics by all health information providers and not just within the National electronic Library for Health, the overall quality of the Web will improve with time and the Web will ultimately become a reliable and integral part of the care space.

Health geomatics: an enabling suite of technologies in health and healthcare.

This Methodolical Review describes how health geomatics can improve our understanding of the important relationship between location and health, and thus assist us in Public Health tasks like disease prevention, and also in better healthcare service planning. The reader is first introduced to health geography and its two main divisions, disease ecology and healthcare delivery, followed by an overview of the basic concepts and principles of health geomatics. Topics covered include geographical information systems (GIS), GIS modeling, and GIS-related technologies (remote sensing and the global positioning system). We also present a number of real-life health geomatics applications and projects, with pointers to further studies and resources. Finally, we discuss the barriers facing the adoption of GIS technology in the health sector, including data availability/quality issues. The authors believe that we still need to combat many cultural and organizational barriers, including "spatial illiteracy" among healthcare workers, while making the tools cheaper and easier to learn and use, before health geomatics can become a mainstream technology in the health sector like today's spreadsheets and databases.

Acute toxicity of organophosphorus and organochlorine insecticides in laboratory animals.

The influence of acute poisoning with Dursban (O.P.I.) and D.D.T. (O.cl.I.) on serum enzymes and histopathological examination of the liver, kidney and testes was investigated in albino rats. Two repeated i.p. injections of Dursban in a dose of half the LD 50 resulted in a significant increase in serum GOT, GPT and alkaline phosphatase activity and a decrease of cholinesterase. In case of DDT, two doses of 150 mg/kg orally resulted in a significant increase in the activity of serum GPT only, while three doses increased serum GOT and GPT. No significant change was observed in serum alkaline phosphatase and cholinesterase activity. Regarding the pathological examination it was found that in animals treated with Dursban there was liver necrosis of mid-zonal type and fatty change at the periphery. In case of DDT the liver cells lost their radial arrangements and showed fatty change. There was cellular infiltration in the centre, mostly mononucleolar cells. In both insecticides there was necrosis of some of the seminiferous tubules of the testes and cloudy swelling of the convoluted tubules of the kidney. Histochemical study of the liver in animals treated with Dursban showed that glycogen was deposited at one side of the cell. However, there was depletion of glycogen around the central vein. In liver treated with DDT there were large globules of fat inside the liver cells, indicating increased fat content compared to control liver, where there were tiny minute droplets of fat.