Assuntos
Aeromonas veronii , Fasciite Necrosante/tratamento farmacológico , Fasciite Necrosante/cirurgia , Infecções por Bactérias Gram-Negativas/tratamento farmacológico , Infecções por Bactérias Gram-Negativas/cirurgia , Aeromonas veronii/isolamento & purificação , Idoso , Antibacterianos/administração & dosagem , Cefepima/administração & dosagem , Ciprofloxacina/administração & dosagem , Terapia Combinada , Tratamento Conservador , Quimioterapia de Consolidação/efeitos adversos , Desbridamento , Quimioterapia Combinada , Fasciite Necrosante/microbiologia , Infecções por Bactérias Gram-Negativas/complicações , Humanos , Leucemia Mieloide Aguda/complicações , Leucemia Mieloide Aguda/tratamento farmacológico , Leucemia Mieloide Aguda/microbiologia , Masculino , Resultado do TratamentoRESUMO
In neonatal intensive care units, topical agents represent an increasing part of the infection control armamentarium. Fifty-one coagulase-negative staphylococci (CNS) isolated from catheter-associated bloodstream infections in very preterm neonates were investigated in this study: 41.2% exhibited decreased susceptibility to at least one antiseptic (chlorhexidine 12%, benzalkonium 24%, acriflavine 33%) and 61% were resistant to mupirocin. QacA/B, mupA and both genes were detected by polymerase chain reaction in 59%, 63% and 49% of CNS, respectively. Seventy-six percent of Staphylococcus epidermidis (5/5 pulsed-field-gel electrophoresis subgroups) and 11% of Staphylococcus capitis (1/3 subgroups) were multi-resistant. Skin antisepsis using low-concentration aqueous formulations and off-label mupirocin indications should benefit from a stewardship programme.
