Clinical and laboratory characteristics in outpatient diagnosis of COVID-19 in healthcare professionals in Rio de Janeiro, Brazil.

AIMS: This study aimed to identify the symptoms associated with early stage SARS-CoV-2 (COVID-19) infections in healthcare professionals (HCPs) using both clinical and laboratory data. METHODS: A total of 1297 patients, admitted between 18 March and 8 April 2020, were stratified according to their risk of developing COVID-19 using their responses to a questionnaire designed to evaluate symptoms and risk conditions. RESULTS: Anosmia/hyposmia (p<0.0001), fever (p<0.0001), body pain (p<0.0001) and chills (p=0.001) were all independent predictors for COVID-19, with a 72% estimated probability for detecting COVID-19 in nasopharyngeal swab samples. Leucopenia, relative monocytosis, decreased eosinophil values, C reactive protein (CRP) and platelets were also shown to be significant independent predictors for COVID-19. CONCLUSIONS: The significant clinical features for COVID-19 were identified as anosmia, fever, chills and body pain. Elevated CRP, leucocytes under 5400×109/L and relative monocytosis (>9%) were common among patients with a confirmed COVID-19 diagnosis. These variables may help, in the absence of reverse transcriptase PCR tests, to identify possible COVID-19 infections during pandemic outbreaks. SUMMARY: From 19 March to 8 April 2020, 1297 patients attended the Polyclinic Piquet Carneiro for COVID-19 detection. HCP data were analysed, and significant clinical features were anosmia, fever, chills and body pain. Elevated CRP, leucopenia and monocytosis were common in COVID-19.

Menstrual cycle alterations during adolescence: early expression of metabolic syndrome and polycystic ovary syndrome.

STUDY OBJECTIVE: To assess the importance of the menstrual pattern as a marker for clinical and laboratory alterations related to metabolic syndrome (MS) and polycystic ovary syndrome (PCOS) among Brazilian adolescents. DESIGN: A cross-sectional study. SETTING: Endocrine Gynecology Outpatient Clinic of the Adolescent Health Studies Center (NESA) at the Pedro Ernesto University Hospital. PARTICIPANTS: 59 girls (12-19 years old) were classified by their menstrual cycles as regular (n = 23) and irregular (n = 36). INTERVENTION: None. MAIN OUTCOME MEASURES: Biochemical collections were made of peripheral blood after fasting for 12 hours, and the oral glucose tolerance test with 75 g of anhydrous glucose. RESULTS: PCOS, MS, and the criteria for MS were significantly more frequent (P < .05) in the subgroup with irregular menstruation. Adolescents with irregular cycles presented a significant increase in waist circumference, glycemia 2 hours after oral glucose overload (2 h), fasting and 2-h insulin, HOMA-IR, and triglycerides. In contrast, the glucose/insulin ratio, quantitative insulin-sensitivity check index, and HDL serum levels were significantly lower among patients with irregular menstruation, compared to those with regular cycles. In the logistic regression, we noted that insulin 2 h ≥ 75 µIU/mL (r = 1.90; P = .018), waist circumference > 95 cm (r = 2.21; P = .006) and diagnosis of PCOS (r = 1.93; P = .023) were significantly correlated to irregular cycles. CONCLUSIONS: We concluded that close observation of menstrual cycle patterns is an important tool for identifying adolescents at higher risk of developing PCOS and MS.

Síncope como forma de presentación de masa mediastínica / Syncope in the debut of a mediastinal mass

El síncope supone el 3 por ciento de las consultas en los servicios deurgencias. En pediatría es frecuente, especialmente en niñas adolescentes de entre 15 y 19 años, quienes hasta un 25 por ciento hansufrido un episodio sincopal. La mayoría de las causas son benignas, pero el objetivo en la evaluación inicial de un paciente con síncope es descartar aquellas que supongan compromiso vital; una enfermedad cardíaca puede debutar en forma de síncope en un 10-28 por ciento de los casos. La historia clínica detallada y una exploración física exhaustiva son suficientes en la mayoría de las situaciones para descartar patología orgánica. Presentamos el caso de un paciente con linfoma B difuso de células grandes localizado en el mediastino cuyo diagnóstico se realizó tras episodios sincopales de repetición.

Síncope como forma de presentación de masa mediastínica / Syncope in the debut of a mediastinal mass

El síncope supone el 3 por ciento de las consultas en los servicios deurgencias. En pediatría es frecuente, especialmente en niñas adolescentes de entre 15 y 19 años, quienes hasta un 25 por ciento hansufrido un episodio sincopal. La mayoría de las causas son benignas, pero el objetivo en la evaluación inicial de un paciente con síncope es descartar aquellas que supongan compromiso vital; una enfermedad cardíaca puede debutar en forma de síncope en un 10-28 por ciento de los casos. La historia clínica detallada y una exploración física exhaustiva son suficientes en la mayoría de las situaciones para descartar patología orgánica. Presentamos el caso de un paciente con linfoma B difuso de células grandes localizado en el mediastino cuyo diagnóstico se realizó tras episodios sincopales de repetición.(AU)

Síncope como forma de presentación de masa mediastínica / Syncope in the debut of a mediastinal mass

El síncope supone el 3 por ciento de las consultas en los servicios deurgencias. En pediatría es frecuente, especialmente en niñas adolescentes de entre 15 y 19 años, quienes hasta un 25 por ciento hansufrido un episodio sincopal. La mayoría de las causas son benignas, pero el objetivo en la evaluación inicial de un paciente con síncope es descartar aquellas que supongan compromiso vital; una enfermedad cardíaca puede debutar en forma de síncope en un 10-28 por ciento de los casos. La historia clínica detallada y una exploración física exhaustiva son suficientes en la mayoría de las situaciones para descartar patología orgánica. Presentamos el caso de un paciente con linfoma B difuso de células grandes localizado en el mediastino cuyo diagnóstico se realizó tras episodios sincopales de repetición.(AU)

Perfil das queimaduras em adolescentes / Profile of burns in adolescents

Introdução: Durante a adolescência, ocorrem mudanças de ordem emocional e na indecisão de como se conduzir, e o adolescente se expõe, com grandes chances de insucessos. O objetivo deste estudo é analisar as queimaduras em adolescentes e fornecer dados para programas de prevenção. Método: Estudo retrospectivo, avaliando idade, sexo, agente causal, local do acidente e mortalidade, em adolescentes queimados. Resultados: Foram avaliados 51 adolescentes entre 12 e 18 anos de idade (média 14,8 anos), sendo 50,98% do sexo feminino. O álcool foi o agente causal mais prevalente (33,33%) e 25,49% dos pacientes possuíam de 20-29% da superfície corporal queimada. Todos os óbitos ocorreram em indivíduos com superfície corporal queimada superior a 40%. Conclusão: São necessários novos estudos que analisem as características envolvendo a queimadura nessa faixa etária, para o desenvolvimento de ações preventivas para tal evento.

Introduction: During adolescence, emotional changes and indecision on how to conduct himself take place, and the adolescent is exposed, with a high chance of failure. The purpose of this study is to analyze the burns in adolescents and provide data for prevention programs. Methods: A retrospective study evaluating age, sex, causal agent, burned site and mortality was performed, in adolescents. Results: This study assessed 51 adolescents between 12 and 18 years old (mean 14.8 years), 50.98% female. Alcohol was the most prevalent causal agent (33.33%), and 25.49% patients had 20-29% of body surface area burned. All deaths occurred in individuals with more than 40% of the body surface area burned. Conclusion: Further studies are needed to examine the characteristics involving the burn in this age group for the development of preventive measures for this event.