Menstrual cycle alterations during adolescence: early expression of metabolic syndrome and polycystic ovary syndrome.

STUDY OBJECTIVE: To assess the importance of the menstrual pattern as a marker for clinical and laboratory alterations related to metabolic syndrome (MS) and polycystic ovary syndrome (PCOS) among Brazilian adolescents. DESIGN: A cross-sectional study. SETTING: Endocrine Gynecology Outpatient Clinic of the Adolescent Health Studies Center (NESA) at the Pedro Ernesto University Hospital. PARTICIPANTS: 59 girls (12-19 years old) were classified by their menstrual cycles as regular (n = 23) and irregular (n = 36). INTERVENTION: None. MAIN OUTCOME MEASURES: Biochemical collections were made of peripheral blood after fasting for 12 hours, and the oral glucose tolerance test with 75 g of anhydrous glucose. RESULTS: PCOS, MS, and the criteria for MS were significantly more frequent (P < .05) in the subgroup with irregular menstruation. Adolescents with irregular cycles presented a significant increase in waist circumference, glycemia 2 hours after oral glucose overload (2 h), fasting and 2-h insulin, HOMA-IR, and triglycerides. In contrast, the glucose/insulin ratio, quantitative insulin-sensitivity check index, and HDL serum levels were significantly lower among patients with irregular menstruation, compared to those with regular cycles. In the logistic regression, we noted that insulin 2 h ≥ 75 µIU/mL (r = 1.90; P = .018), waist circumference > 95 cm (r = 2.21; P = .006) and diagnosis of PCOS (r = 1.93; P = .023) were significantly correlated to irregular cycles. CONCLUSIONS: We concluded that close observation of menstrual cycle patterns is an important tool for identifying adolescents at higher risk of developing PCOS and MS.

Perfil das queimaduras em adolescentes / Profile of burns in adolescents

Introdução: Durante a adolescência, ocorrem mudanças de ordem emocional e na indecisão de como se conduzir, e o adolescente se expõe, com grandes chances de insucessos. O objetivo deste estudo é analisar as queimaduras em adolescentes e fornecer dados para programas de prevenção. Método: Estudo retrospectivo, avaliando idade, sexo, agente causal, local do acidente e mortalidade, em adolescentes queimados. Resultados: Foram avaliados 51 adolescentes entre 12 e 18 anos de idade (média 14,8 anos), sendo 50,98% do sexo feminino. O álcool foi o agente causal mais prevalente (33,33%) e 25,49% dos pacientes possuíam de 20-29% da superfície corporal queimada. Todos os óbitos ocorreram em indivíduos com superfície corporal queimada superior a 40%. Conclusão: São necessários novos estudos que analisem as características envolvendo a queimadura nessa faixa etária, para o desenvolvimento de ações preventivas para tal evento.

Introduction: During adolescence, emotional changes and indecision on how to conduct himself take place, and the adolescent is exposed, with a high chance of failure. The purpose of this study is to analyze the burns in adolescents and provide data for prevention programs. Methods: A retrospective study evaluating age, sex, causal agent, burned site and mortality was performed, in adolescents. Results: This study assessed 51 adolescents between 12 and 18 years old (mean 14.8 years), 50.98% female. Alcohol was the most prevalent causal agent (33.33%), and 25.49% patients had 20-29% of body surface area burned. All deaths occurred in individuals with more than 40% of the body surface area burned. Conclusion: Further studies are needed to examine the characteristics involving the burn in this age group for the development of preventive measures for this event.