1.
Bioorg Med Chem Lett
; 8(9): 1123-6, 1998 May 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-9871720
RESUMO
A novel solid-phase synthesis of 5'-radiolabeled oligonucleotides is described. The labeling reaction is carried out by the phosphoramidite method with the aid of [4,6-di-14C]-5'-dimethoxytritylthymidine building block 1. The feasibility of the method is demonstrated by preparation of 3'-phosphorylated dodecathymidylate phosphorothioate containing radiolabeled nucleoside at the 5'-terminus.