RESUMO
The aim of this study was to test for the existence of causative genetic variation affecting body composition traits within or adjacent to the porcine insulin-like growth factor 2 (IGF2) gene beyond the known IGF2-intron3-G3072A mutation. A focussed quantitative trait loci analysis using four microsatellite markers within the telomeric region of porcine chromosome 2p was conducted in a large resource population comprising 2741 F2 offspring. The analysis of two subsets of animals that were alternatively homozygous for the in3G3072A mutation provides evidence for additional genetic variation significantly contributing to the overall quantitative trait nucleotide variance within our population.
RESUMO
The distal part of SSC7, which contains the ortholog to the ovine region encompassing the callipyge locus, was analyzed in a Piétrain F(2) resource population comprising more than 2,700 offspring. The aim of the study was to map QTL affecting carcass traits comparable with the callipyge phenotype in sheep. We applied an interval mapping approach using 14 microsatellite markers and detected 3 QTL with small effects. The first QTL affects fat thickness on the middle of the back, with no detectable impact on fat sizes at other places on the back, whereas the second QTL affects side fat thickness. The third QTL influences the ham weight and shows a clear parent-of-origin-dependent effect in the form of maternal polar overdominance. It is not located at the position of the imprinting cluster including the callipyge locus, but 7 cM proximal.
Assuntos
Peso Corporal/genética , Carne/normas , Locos de Características Quantitativas/genética , Suínos/genética , Animais , Composição Corporal/genética , Feminino , Genes Dominantes/genética , Ligação Genética/genética , Genótipo , Masculino , Repetições de Microssatélites/genética , Músculo Esquelético/crescimento & desenvolvimento , Fenótipo , Ovinos/genéticaRESUMO
The Lapidus operation for correction of severe hallux valgus with metatarsus primus varus has never been well accepted by foot surgeons. The main reason for this has been the poor results obtained from its misuse. Lapidus strongly advocated the operation as a virtual panacea for correction of all degrees of severity of these deformities in both young and old patients. The technique, however, is appropriate for severe metatarsus primus varus with hallux valgus, in the foot with marked first ray hypermobility and collapsed distal-medial arch. The purpose and proper indications for the Lapidus operation are discussed, and the technique is illustrated.
Assuntos
Anormalidades Múltiplas/cirurgia , Hallux Valgus/cirurgia , Metatarso/anormalidades , Osteotomia/métodos , Parafusos Ósseos , Humanos , Metatarso/cirurgiaRESUMO
Cases of tophaceous gout amenable to surgical management may be encountered in a podiatric practice. This paper reviews the indications for surgery, the pathology, the principles of surgical technique, the preoperative and postoperative management, and presents a case report.
