Enhanced quantum interface with collective ion-cavity coupling.

We prepare a maximally entangled state of two ions and couple both ions to the mode of an optical cavity. The phase of the entangled state determines the collective interaction of the ions with the cavity mode, that is, whether the emission of a single photon into the cavity is suppressed or enhanced. By adjusting this phase, we tune the ion-cavity system from sub- to superradiance. We then encode a single qubit in the two-ion superradiant state and show that this encoding enhances the transfer of quantum information onto a photon.

Quantum-state transfer from an ion to a photon.

One model for quantum networks1,2 is based on the probabilistic measurement of two photons, each entangled with a distant node, e.g., an atom or atomic ensemble3-7. A second, deterministic model transfers information directly from an atom onto a cavity photon, which carries it to a second node8, as recently demonstrated with neutral atoms9. In both cases, the challenge is to transfer information efficiently while preserving coherence. Here, following the second scheme, we map the quantum state of an ion onto a photon within an optical cavity. Using an ion enables deterministic state initialization10,11, while the cavity provides coherent coupling to a well-defined output mode12-15. Although it is often assumed that a cavity-based quantum interface requires the strong-coupling regime, we show transfer fidelities of 92% in the presence of non-negligible decoherence and characterize the interplay between fidelity and efficiency. Our time-independent mapping process offers a promising route toward ion-based quantum networks.

Integrated fiber-mirror ion trap for strong ion-cavity coupling.

We present and characterize fiber mirrors and a miniaturized ion-trap design developed to integrate a fiber-based Fabry-Perot cavity (FFPC) with a linear Paul trap for use in cavity-QED experiments with trapped ions. Our fiber-mirror fabrication process not only enables the construction of FFPCs with small mode volumes, but also allows us to minimize the influence of the dielectric fiber mirrors on the trapped-ion pseudopotential. We discuss the effect of clipping losses for long FFPCs and the effect of angular and lateral displacements on the coupling efficiencies between cavity and fiber. Optical profilometry allows us to determine the radii of curvature and ellipticities of the fiber mirrors. From finesse measurements, we infer a single-atom cooperativity of up to 12 for FFPCs longer than 200 µm in length; comparison to cavities constructed with reference substrate mirrors produced in the same coating run indicates that our FFPCs have similar scattering losses. We characterize the birefringence of our fiber mirrors, finding that careful fiber-mirror selection enables us to construct FFPCs with degenerate polarization modes. As FFPCs are novel devices, we describe procedures developed for handling, aligning, and cleaning them. We discuss experiments to anneal fiber mirrors and explore the influence of the atmosphere under which annealing occurs on coating losses, finding that annealing under vacuum increases the losses for our reference substrate mirrors. X-ray photoelectron spectroscopy measurements indicate that these losses may be attributable to oxygen depletion in the mirror coating. Special design considerations enable us to introduce a FFPC into a trapped ion setup. Our unique linear Paul trap design provides clearance for such a cavity and is miniaturized to shield trapped ions from the dielectric fiber mirrors. We numerically calculate the trap potential in the absence of fibers. In the experiment additional electrodes can be used to compensate distortions of the potential due to the fibers. Home-built fiber feedthroughs connect the FFPC to external optics, and an integrated nanopositioning system affords the possibility of retracting or realigning the cavity without breaking vacuum.

Heralded entanglement of two ions in an optical cavity.

We demonstrate precise control of the coupling of each of two trapped ions to the mode of an optical resonator. When both ions are coupled with near-maximum strength, we generate ion-ion entanglement heralded by the detection of two orthogonally polarized cavity photons. The entanglement fidelity with respect to the Bell state Ψ+ reaches F≥(91.9±2.5)%. This result represents an important step toward distributed quantum computing with cavities linking remote atom-based registers.

Tunable ion-photon entanglement in an optical cavity.

Proposed quantum networks require both a quantum interface between light and matter and the coherent control of quantum states. A quantum interface can be realized by entangling the state of a single photon with the state of an atomic or solid-state quantum memory, as demonstrated in recent experiments with trapped ions, neutral atoms, atomic ensembles and nitrogen-vacancy spins. The entangling interaction couples an initial quantum memory state to two possible light-matter states, and the atomic level structure of the memory determines the available coupling paths. In previous work, the transition parameters of these paths determined the phase and amplitude of the final entangled state, unless the memory was initially prepared in a superposition state (a step that requires coherent control). Here we report fully tunable entanglement between a single (40)Ca(+) ion and the polarization state of a single photon within an optical resonator. Our method, based on a bichromatic, cavity-mediated Raman transition, allows us to select two coupling paths and adjust their relative phase and amplitude. The cavity setting enables intrinsically deterministic, high-fidelity generation of any two-qubit entangled state. This approach is applicable to a broad range of candidate systems and thus is a promising method for distributing information within quantum networks.

Frequency of rpoB mutations inside and outside the cluster I region in rifampin-resistant clinical Mycobacterium tuberculosis isolates.

The prevalence of recently described mutation V176F, located in the beginning of the rpoB gene and associated with rifampin resistance and the wild-type cluster I sequence, was determined by analyzing the distribution of rpoB mutations among 80 rifampin (RIF)-resistant Mycobacterium tuberculosis strains isolated in Germany during 1997. The most frequent rpoB mutations were changes in codon 456 (52 isolates, 65%), followed by changes in codon 441 (13 isolates, 16%) and codon 451 (11 isolates, 14%). The V176F mutation was detected in one isolate of the study population and in 5 of 18 RIF-resistant strains with no cluster I mutation from six previously published studies. In three isolates, a mixture of resistant and susceptible subpopulations (heteroresistance) prohibited the detection of rpoB mutations in the initial analysis; however, in these isolates, cluster I mutations could be verified after a passage on RIF-containing medium. IS6110 DNA fingerprinting of 76 strains revealed eight clusters comprising 27 strains with identical restriction fragment length polymorphism patterns that mainly also show identical rpoB mutations and identical or similar drug resistance patterns. In conclusion, our results indicate that the V176F mutation should be included in molecular tests for prediction of RIF resistance in M. tuberculosis. We further demonstrated that heteroresistance caused by a mixture of mycobacterial subpopulations with different susceptibilities to RIF may influence the sensitivity of molecular tests for detection of resistance.

[Hemodynamic effects of an osmotic bolus for the reversible opening of the blood-brain barrier]. / Hämodynamische Auswirkung eines osmotischen Bolus zur reversiblen Eröffnung der Bluthirnschranke.

Reversible opening of the blood-brain barrier before administration of watersoluble cytoreductive agents constitutes a new tool in the treatment of central nervous malignancies. In this study a volume of 172 ml mannitol 25% has been injected into one of the cerebral arteries within 30 seconds. 5 minutes later the osmolality had augmented from 286 to 303 mosmol/kg and the plasma volume by 15%. The hemodynamic measurements--cardiac index (+47%), heart rate (+7%), LVSWI (+50%), systemic vascular resistance (-20%) and blood volume (+15%)--indicate a biphasic response with early fall in SVR followed by a rise in cardiac performance which is independent of the preload.