RESUMO
Aspects of the renal function were assessed in rats treated with the pentavalent antimonials Glucantime (Meglumine Antimoniate, Rhodia) or Pentostam (Sodium Stibogluconate, Wellcome). In dose of 30 mg of Sbv (Glucantime or Pentostam) by 100 mg of weight by day for 30 days, renal functional changes were observed consisting of disturbances in urine concentrating capacity. Such disturbances were expressed by significantly low values of urine osmolality as compared to the basal values previous to the drugs. The decrease in urine osmolality was associated to a significant increase in urinary flow and in negative free-water clearance. There was no alteration in osmolar clearance and in fractional excretion of sodium. These observations suggest an interference of the drugs in the action of the antidiuretic hormone. The disturbance in urine concentration was reversible after a seven days period without the drugs administration. No significant histopathological alterations were observed in the kidneys of the rats treated with the drugs. On the other hand, the rats treated with a high dose of Pentostam (200 mg/100 grams of weight/day) showed the functional and the histopathological alterations of the acute tubular necrosis.
Assuntos
Antiprotozoários/toxicidade , Rim/efeitos dos fármacos , Meglumina/toxicidade , Compostos Organometálicos/toxicidade , Animais , Capacidade de Concentração Renal/efeitos dos fármacos , Masculino , Antimoniato de Meglumina , Concentração Osmolar , Ratos , Ratos Endogâmicos , Sódio/metabolismo , Água/metabolismoAssuntos
Antipirina/metabolismo , Esquistossomose/metabolismo , Adolescente , Adulto , Antipirina/administração & dosagem , Feminino , Meia-Vida , Humanos , Fígado/metabolismo , Hepatopatias Parasitárias/metabolismo , Masculino , Taxa de Depuração Metabólica , Pessoa de Meia-Idade , Schistosoma mansoni , Esquistossomose/complicações , Esplenopatias/metabolismoAssuntos
Infecções por Clostridium/microbiologia , Clostridium perfringens/isolamento & purificação , Manipulação de Alimentos , Microbiologia de Alimentos , Doenças Profissionais/microbiologia , Matadouros , Adolescente , Adulto , Brasil , Infecções por Clostridium/epidemiologia , Fezes/microbiologia , Feminino , Mãos/microbiologia , Humanos , Masculino , Doenças Profissionais/epidemiologiaRESUMO
Previous studies have indicated toxoplasmosis and Q fever are potential hazards to persons who handle raw meat or who work in slaughterhouses. The prevalence of antibodies to T. gondii and C. burneti was studied among 144 employees of an abattoir in Belo Horizonte, Brazil, to determine what environmental factors may be associated with the occurrence of these agents among persons who handle meat but who have not reported having toxoplasmosis or Q fever. Seventy-two per cent of the 144 employees were serologically positive to T. gondii and 29% were serologically positive for C. burneti. The highest prevalence of antibodies to T. gondii (92%) occurred among meat inspectors, who also had a geometric mean titer (GMT) of 1400. The prevalence levels of antibodies to T. gondii for employees who handled meat in the deboning and sausage departments were 80% and 79% with GMT's of 412 and 340, respectively. These levels exceeded the antibody prevalences of 60% and 65% and GMT's of 168 and 120 for employees who worked with cattle in the corrals or who worked on the killing floor, respectively. Conversely, the prevalence of antibodies to C. burneti was highest (40%) among employees working in the corrals and who were exposed to dust and hides. A similar prevalence of antibodies to C. burneti was found in employees on the killing floor (36% positive) who were exposed to hides and viscera, but employees handling meat in the deboning or sausage section had prevalence levels of 20% and 14% respectively. Serologic testing of zebu cattle processed at the abattoir indicated that 10% of 124 tested had antibodies to T. gondii and 29% of 156 tested had antibodies to C. burneti. These levels in cattle are probably adequate to expose (and infect) persons who process meat daily. Continuous daily exposures to chronically infected cattle may result in sporadic undiagnosed illnesses or seroconversions from subclinical infections.
Assuntos
Matadouros , Doenças Profissionais/epidemiologia , Febre Q/epidemiologia , Toxoplasmose/epidemiologia , Adolescente , Adulto , Brasil , Feminino , Humanos , Masculino , Indústria de Embalagem de Carne , Pessoa de Meia-Idade , Fatores SexuaisAssuntos
Circulação Cerebrovascular , Cateterismo , Artéria Femoral , Humanos , Veias Jugulares , Criptônio , Métodos , RadioisótoposAssuntos
Circulação Hepática , Fígado/metabolismo , Consumo de Oxigênio , Animais , Cães , Artéria Hepática , Criptônio , Veia Porta , RadioisótoposRESUMO
Patients with chronic liver disease, yet without severe encephalopathy, were found to show evidence of increased brain utilization of glucose. The changes were abolished after an intravenous infusion of 15 g ornithine alpha oxoglutarate, given over a period of 15 minutes. The possible implications of these observations are discussed.