[The dynamics of clinical and functional condition of patients with different variants of coronary heart disease course during the period of long-term outpatient follow-up].

With the purpose to study clinical and functional parameters of coronary heart disease (CHD) course, the authors carried out a complex examination of 376 patients (308 men and 68 women). The evolution of their psychophysiological condition was evaluated after 1, 3, 5, and 7 years. 3 variants of disease course were distinguished: 1--clinical remission--was observed in 27 (7.1%) patients; 2--stable CHD course--in 263 (69.9%) patients; 3--complicated CHD course--in 86 (23%) patients. The complicated disease course was characterized by increasing clinical manifestations of angina with myocardial contractility impairment, shorter remission periods, low activity tolerance, and persistent hypercholesterinemia. These patients had persistent hypochondric and depressive manifestations of psychoemotional disadaptation, which confirms the interrelation between the disease and psychosomatic disturbances. Regression analysis proved high informative value of a range of clinical parameters, which allow verification of diagnostical process during long-term follow-up, and improvement of treatment quality.

Oligopeptides in the regulation of feeding and avoidance behaviour in the land snail (Helix lucorum).

The effects of the oligopeptides pentagastrin, cholecystokinin octapeptide, substance P, and FMRF-amide on the feeding and avoidance behaviour of the land snail Helix lucorum were studied. Administration of 1 microM pentagastrin to fasted snails immediately before feeding led to a significant increase in the amount of food consumed in the first 20 min of the feeding period, although there was no change in the total amount of food consumed. Prefeeding injections of 0.05 microM pentagastrin or 0.05 microM or 1 microM solutions of cholecystokinin octapeptide, substance P, or FMRF-amide had no effect on feeding behaviour. Pentagastrin and cholecystokinin octapeptide (0.05 microM solutions) invoked a significant reversible decrease in the generalised avoidance reaction thresholds in fasted but not in prefed snails, whereas the same concentration of FMRF-amide reduced these thresholds only in prefed snails.