1.
Bioorg Med Chem Lett
; 16(23): 6112-5, 2006 Dec 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16979338
RESUMO
A mimic of the putative transition-state intermediate has been synthesized and found to be a very slow-onset inhibitor of yeast orotate phosphoribosyltransferase. The mechanism of inhibition may involve a rate-determining isomerization of the enzyme to a form receptive to the inhibitor, which then remains tightly bound.