[Pharmaco -- genetic approach to the improvement of beta-adrenoblocker therapy in the treatment of hypertension]. / Farmakogeneticheskii podkhod k optimizatsii terapii gipertonicheskoi bolezni beta-adrenoblokatorami.

A relationship between individual variations of the oxidative and acetylating metabolism rates of penbutolol, propranolol, acebutolol which produce a hypotensive effect was studied in patients with arterial hypertension. A study was performed in groups of patients, which comprised 22, 22, and 20 males, respectively. They all suffered from Stage II hypertensive disease. There was a predominant number of patients with partial and complete antihypertensive benefits in those with low oxidation rates than in those with high oxidative metabolism rates when penbutolol (89 and 54%, respectively; p < 0.05) and propranolol (78 and 31%, respectively; p < 0.01) were given. A graphic analysis of changes in blood pressure, which had been observed during a course monotherapy with penbutolol and propranolol identified two groups of patients differing in having benefits. Within each group, the relationship between the decrease in diastolic blood pressure to the elimination half-life of parmidine is described by a linear regression equation and it has a high positive correlation coefficient.

[Drug-metabolizing activity of the liver in patients with eczema and allergic dermatitis]. / Farmakometaboliziruiushchaia aktivnost' pecheni u bol'nykh ékzemoi u allergicheskim dermatitom.

Antipyrine test has been used to assess drug metabolism of the liver in 43 subjects, including 20 patients suffering from eczema and allergic dermatitis. "Rapid" oxidizers predominated among the patients; tissue barrier permeability for the test agent has been increased in eczema patients. These data should be borne in mind when prescribing the drugs that are subjected mainly to oxidizing metabolism, primarily antiinflammatory agents, to patients suffering from allergic dermatoses.

[Effect of plasmids on the multiplication indices of Escherichia coli]. / O vliianii plazmid na pokazateli razmnozheniia kishechnoi palochki.

The mechanisms of plasmid effect on multiplication of bacterial populations were studied. 22 different plasmids of antibiotic resistance, colicinogenicity and hemolytic activity were tested for their effect on the lag period and generation time of 1 smooth and 2 rough strains of E coli in comparison to the clonal structure of the respective plasmid variants with respect to the property of formation of rough mutants and in comparison to the molecular weight of the plasmids. There was a good agreement between the lag period, generation time, relative content of rough mutants in the population and molecular weights of the respective plasmids. It is suggested that the effect of the decreased intensity of bacterial population multiplication due to its infection with the plasmids is likely to be connected with accumulation of rough mutants having a lower multiplication rate.