RESUMO
We studied a patient with a grossly black thyroid gland considered to be related to minocycline therapy. Microscopically, a brown granular pigment was localized in follicular cells and colloid, which histochemically was melanin or a melaninlike substance. Ultrastructurally, the pigment is confined to lysosomes. The pigment seems to be either an oxidative degradation product of the drug itself, or the results of an as yet unknown alteration of tyrosine metabolism by the drug. Although minocycline is known to interfere with thyroid function in animals, no evidence has been presented for such an effect in humans. The occurrence of a black thyroid gland in humans seems to be virtually pathognomonic for long-term minocycline therapy.
Assuntos
Minociclina/efeitos adversos , Transtornos da Pigmentação/induzido quimicamente , Tetraciclinas/efeitos adversos , Doenças da Glândula Tireoide/induzido quimicamente , Glândula Tireoide/patologia , Humanos , Lisossomos/ultraestrutura , Masculino , Melaninas/análise , Pessoa de Meia-Idade , Minociclina/metabolismo , Transtornos da Pigmentação/patologia , Rosácea/tratamento farmacológico , Doenças da Glândula Tireoide/patologia , Glândula Tireoide/ultraestrutura , Tirosina/metabolismoRESUMO
A rare case of primary solitary amyloidoma involving the dorsal spine is reported. Destruction of the fourth thoracic vertebra and extension of the soft tissue mass around the vertebra were visualized on linear tomography and computed tomography. Diagnosis was made on the basis of histology and histochemical reactions.
Assuntos
Amiloide/análise , Neoplasias da Coluna Vertebral/diagnóstico por imagem , Idoso , Amiloidose/diagnóstico , Biópsia , Diagnóstico Diferencial , Histocitoquímica , Humanos , Masculino , Neoplasias do Mediastino/diagnóstico por imagem , Invasividade Neoplásica , Radiografia Torácica , Neoplasias da Coluna Vertebral/metabolismo , Tomografia , Tomografia Computadorizada por Raios XRESUMO
A 6-year experience with bone marrow aspirates and biopsies (96 cases) positive for metastatic carcinoma is reviewed. Marrow examination detected secondary carcinoma in 58 cases (60%) despite negative roentgenographic and/or bone scan examinations. Breast carcinoma was the most frequent primary site. The bone marrow biopsy was superior to the aspirate in finding carcinoma (97% vs. 72%). However, in an occasional case, tumor was found only in aspirate preparations. Both procedures should be considered complementary and are recommended in the marrow evaluation of patients with carcinoma.
Assuntos
Doenças da Medula Óssea/diagnóstico , Exame de Medula Óssea/métodos , Metástase Neoplásica/diagnóstico , Biópsia por Agulha , Humanos , SucçãoRESUMO
An infant had supraventricular tachycardia and massive anasarca at birth. The supraventricular tachycardia and congestive heart failure were minimally responsive to medical therapy. At 1 month of age, a diagnosis of atrial and ventricular septal defect was made by cardiac catheterization. At 5 months of age, at an operation for pulmonary banding, a peculiar neoplasm of the right atrium was noted. On clamping and resection of the neoplasm, the supraventricular tachyarrhythmia reverted to normal sinus mechanism. The neoplasm, by light and electron microscopy, was thought to be a conduction system hamartoma and was thought to have caused the arrhythmia. A review of the literature showed that no such lesions had been reported previously.
