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1.
Croat Med J ; 65(3): 261-267, 2024 Jun 13.
Artigo em Inglês | MEDLINE | ID: mdl-38868972

RESUMO

Traditional newborn screening (NBS) serves as a critical tool in identifying conditions that may impact a child's health from an early stage. Newborn sequencing (NBSeq), the comprehensive analysis of an infant's genome, holds immense promise for revolutionizing health care throughout the lifespan. NBSeq allows for early detection of genetic disease risk and precision personalized medicine. The rapid evolution of DNA sequencing technologies and increasing affordability have spurred numerous endeavors to explore the potential of whole-genome sequencing in newborn screening. However, this transformative potential cannot be realized without challenges. Ethical aspects must be carefully navigated to safeguard individual rights and maintain public trust. Moreover, genomic data interpretation poses complex challenges due to its amount, the presence of variants of uncertain significance, and the dynamic nature of our understanding of genetics. Implementation hurdles, including cost, infrastructure, and specialized expertise, also present barriers to the widespread adoption of NBSeq. Addressing these challenges requires collaboration among clinicians, researchers, policymakers, ethicists, and stakeholders across various sectors. Robust frameworks for informed consent, data protection, and governance are essential. Advances in bioinformatics, machine learning, and genomic interpretation are crucial for translation into actionable clinical insights. Scalability and improving downstream health care access are vital for equitability, particularly in underserved communities. By fostering interdisciplinary collaboration, advancing technology and infrastructure, and upholding ethical principles, we can unlock the full potential of NBSeq as a tool for precision medicine and pave the way toward a future where every child has the opportunity for a healthier, genomics-informed start to life.


Assuntos
Triagem Neonatal , Humanos , Triagem Neonatal/ética , Triagem Neonatal/métodos , Triagem Neonatal/normas , Recém-Nascido , Testes Genéticos/ética , Testes Genéticos/métodos , Sequenciamento Completo do Genoma/ética , Genômica/ética , Medicina de Precisão/métodos
2.
Acta Dermatovenerol Croat ; 31(4): 220-222, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38651849

RESUMO

While basal cell carcinoma is the most common type of skin cancer in humans, its subepidermal presentation is extremely rare. The risk factors for basal cell carcinoma development are well-known, but it remains unclear in which setting the tumor restricts itself to the dermal compartment. We present the fifth known case of subepidermal basal cell carcinoma. However, this particular presentation is unique due to arising beneath a capillary malformation. The patient had previously undergone multiple laser treatments which yielded no success. Initially, the vascular malformation was removed and sent for histopathological diagnosis. After the discovery of basal cell carcinoma, wide surgical resection was performed. The patient had no recurrence up to the last follow-up at 18 months postoperatively. This case demonstrates a new presentation of a very rare condition, but also highlights the importance of histopathological examination and the need for future research on any possible association between laser therapy and carcinogenesis.


Assuntos
Capilares , Capilares/anormalidades , Carcinoma Basocelular , Terapia a Laser , Neoplasias Cutâneas , Malformações Vasculares , Humanos , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/cirurgia , Carcinoma Basocelular/cirurgia , Carcinoma Basocelular/patologia , Terapia a Laser/efeitos adversos , Capilares/patologia , Malformações Vasculares/cirurgia , Malformações Vasculares/diagnóstico , Masculino , Feminino
3.
Dev Neuropsychol ; 34(3): 284-95, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-19437204

RESUMO

The present study asked whether the ability to mentally rotate animal pictures was associated with orientation errors of aiming movements in 7- to 10-year-old children and adults. Mental rotation involves a mental change of the encoded picture's orientation, and one has to determine movement vector orientation in motor programming. In the children, slower rotations were related to higher absolute orientation errors, and less correct responses with movements rightward of the target. No significant correlations were found in adults. This result suggests that in children, motor control and mental rotation may be related through orientation specification processes.


Assuntos
Processos Mentais/fisiologia , Movimento/fisiologia , Orientação/fisiologia , Rotação , Fatores Etários , Criança , Feminino , Humanos , Masculino , Testes Neuropsicológicos , Estimulação Luminosa/métodos , Estatística como Assunto
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