[The study of seasonal variability in the rehabilitation of bronchial asthma]. / Badanie zmiennosci okolorocznej skutecznosci rehabilitacji w astmie oskrzelowej.

The aim of the study was to ascertain whether the seasons of the year influence the course of mild or moderate bronchial asthma, and to assess the effectiveness of respiratory kinesitherapy. In outpatients one month cycles of respiratory kinesitherapy were performed (twice a week for 45 min.) and were still repeated three times in the next seasons of the year. Spirometric and psychological examinations and also the self-evaluation of dyspnea were performed before and after each cycle. Additionally PEF was self-measured by the patients every day. It has been shown that seasons of the year influence neither the values of spirometric parameters of lung ventilation, the circadian rhythm of PEF, nor the effectiveness of respiratory kinesitherapy. However, the repeated cycles of effective breathing favourably influenced the psychic condition and reduced the subjective feeling of dyspnea, as well as improved the quality of asthmatics' life.

[Biology of house dust mites (Acari: Astigmata: Pyroglyphidae)]. / Biologia roztoczy kurzu domowego (Acari: Astigmata: Pyroglyphidae).

This article is a first part of the rewiev of the house-dust-mite-atopy problem data. It includes informations on biology of these mites with emphasis of medical aspect and control. We hope that these informations will be of considerable interest to many readers because of the greatly increased investigations into the role of house dust mite sensitivity in allergic diseases.

[The values of selected lipid parameters and atrial pressure in persons with hyperinsulinemia and normal glucose tolerance]. / Wartosci wybranych parametrów gospodarki lipidowej i cisnienia tetniczego u osób z hiperinsulinemia i prawidlowa tolerancja weglowodanów.

In 60 healthy non-obese persons we determined fasting plasma insulin concentrations. Afterwards we performed test with oral load with 75 g glucose. We determined plasma concentration of insulin one hour and two hours after this load; we found that 14 of 60 subjects had hyperinsulinemia with normal glucose tolerance. In the group of persons with hyperinsulinaemia we have shown the increase of fasting plasma triglyceride levels and elevated diastolic blood pressure. We suggested that healthy persons with hyperinsulinemia and normal glucose tolerance have an increase risk for cardiovascular diseases.

[Typical food allergens for pollinosis in selected regions of Poland. Multiagent studies]. / Alergeny pokarmowe typowe dla pylkowicy w wybranych regionach Polski. Badanie wieloosrodkowe.

The analysis of the incidence of the positive prick test with food allergens among patients with pollen allergy was performed. The 270 patients with pollinosis from four allergy centres in Poznan, Lódz and Katowice were examined. In each centres the different results were obtained. The influence for this had the different status socioeconomic of the patients, the regional habits of eating, and often eating the new products in our country. However, among examination patients the most positive test with food allergens from all centres were nuts, celery, rye flour, carrot, strawberry, pork and beans. The succession of this food allergens were changed in four examination centres in respect to the number of made prick test but the same allergens had been repeated. These results premises to establish the list of the allergens that are needed during diagnosis the patients with pollinosis.

[The incidence of peculiar IgE in response to inhalant allergens in relation to the age of the patient]. / Czestosc wystepowania swoistych IgE na alergeny wziewne w odniesieniu do wieku chorego.

208 patients between the age of 1 month to 56 years, with symptoms of respiratory tract allergy were investigated. In all cases serum titre of sIgE to birch, thymoty, rye, mugwort pollen, Alternaria Alternata, dog, cat fur, Dermatophagoides pteronyssinus and farinae was determined with the use of Quidel immunoenzymatic method. We have found sIgE to Alternaria Alternata in 8 (38%), birch pollen in 5 (23.8%) dog fur in 5 (23.8%) and thymoty and rye pollen in 3 (14.3%) even among one years-old infants. In the second and third years of life allergy to dog fur, Alternaria Alternata and pollen of birch, thymoty and rye increases while the age of 4 and 5 is less significant, later (6-10 years old patients) increases again. Among teenagers pollinosis gets decreases and adults have development constant level of the disease.

[Evaluation of the efficacy of immunotherapy with allergovit and catalet in patients with hay fever--multidrug evaluations]. / Ocena skutecznosci odczulania preparatami Allergovit i Catalet chorych na pylkowice--badania wieloosrodkowe.

UNLABELLED: The aim of this study was to compare the efficacy of the immunotherapy by Allergovit and Catalet. 699 patient in age 5-56 were desensitized. 213 were given Allergovit: 137 in one season, 56 in two seasons and 20 in three seasons and 484 were given Catalet: 288 in one season, 151 in two seasons and 45 in three seasons. The Catalet vaccine contains 12 grasses, rye and plantain pollen, but Allergovit contains a group of grass pollen-60% and rye pollen-40%. Qualification to the desensensitization was performed on the ground of clinics symptoms, positive (+ + + +) prick skin tests, of specific antibody IgE, positive provocation nose test presence and symptoms connected with pollen fall checked every day in the area of Poznan, Lódz and Katowice city. Estimation of the immunotherapy efficiency was assessed by patients, who noted their remarks in prepared "Patient card" using enclose score. In result of desensitization by Allergovit we achieved good and very good improvement (0 + 1 score) after one desensitization season in 77.3% patients, after two seasons in 85.7% and after three seasons in 90.0%, on the contrary by patients desensibilized by Catalet results good and very good were achieved in 50% after one season, after two seasons in 63.6% and after three seasons in 77.8%. CONCLUSIONS: Better results were achieved in patients desensibilized by Allergovit than Catalet. It is necessary of compose the contain of Catalet vaccine for every patient.

Grass pollen immunotherapy induces highly cross-reactive IgG antibodies to group V allergen from different grass species.

Sera from two groups of patients receiving grass pollen immunotherapy were tested on IgG reactivity with group V allergen from six different grass species. One group of patients was treated with a mixture of 10 grass species, and the other with a mixture of five. Only Lolium perenne, Dactylis glomerata, and Phleum pratense were present in both mixtures. Although Anthoxanthum odoratum and Secale cereale were absent from the mixture of five, IgG responses to Ant o V and Sec c V were comparable in both patient groups. This reactivity was inhibited for 92-99% with L. perenne extract, illustrating the cross-reactive nature of the IgG antibodies. The presence of A. odoratum and S. cereale in the mixture resulted in only minor amounts of species-specific anti-group V IgG. These results indicate that application of just one grass species in immunotherapy might be sufficient to induce an IgG response that covers other relevant Gramineae species as well.

[Natural history of allergic reactions to Hymenoptera insect bites]. / Historia naturalna odczynów alergicznych wywolywanych uzadleniami owadów blonkoskrzydlych.

In 30 patients suffering from systemic allergic reactions following Hymenoptera insect bites risk factors have been evaluated. Life-style, place of living, patients' age, sex and the presence of atopy have been considered. Moreover, the clinical course and value of the intracutaneous quantitative tests have been analysed and their value in both the diagnosis and prognosis of the said reactions have been assessed. Significant correlation between the results of quantitative diagnostic tests and severity of the hypersensitivity to insect poison has been found. A phenomena of the spontaneous diminished skin reactions has been noted. It has been found that only an individual analysis of the natural history might be a base for the choice of appropriate therapy.

[Clinical and rhino-manometric evaluation of flunisolide in treatment of seasonal allergic rhinitis]. / Kliniczna i rinomanometryczna ocena skutecznosci flunizolidu w leczeniu alergicznego sezonowego niezytu nosa.

24 patients with seasonal allergic rhinitis (SAR) were observed. Persons with nasal obstruction caused by other mechanisms than allergy to pollens were excluded. The increase of nasal resistance and complaints after begin of pollen season was statistically significant. The clinical efficacy of topical flunisolide in patients with SAR was evaluated. The significant building of symptoms scores and increase of rhinomanometric measured nasal patency were noted.

[Correlation between symptoms and results of rhinomanometric measurements of nasal patency in patients with seasonal allergic rhinitis]. / Zwiazek miedzy samopoczuciem a wynikami rinomanometrycznych pomiarów droznosci nosa u chorych na sezonowy niezyt nosa.

The aim of presented study were to assess the usefulness of rhinomanometry in monitoring course of disease and effectivity of treatment in seasonal allergic rhinitis (SAR) through answering the question whether and eventually which relationship exists between patient's general feeling and results of rhinomanometric measurements of nasal patency (NP). The study involved 114 subjects with SAR divided into 3 groups dependent on phase of disease and severity of complaints and 30 healthy volunteers. For results see table I. Nasal flow and resistance measured at differential pressure 75 Pa in groups I, III and IV did not differ significantly. In group II nasal flow values were lower (alpha < 0.001) and resistance values higher (alpha < 0.001) as compared with remaining groups. Thus, the beginning of symptoms is related to lowering of NP as compared with symptom-free phase of SAR. In the symptom-free period NP do not differ from healthy population. The results of rhinomanometric measurements of NP are useful in monitoring of course of SAR in assessment of effectivity of treatment.

[Long term results of treatment with cytostatic drugs on respiratory function tests in children]. / Odlegly wplyw leczenia cytostatykami na wyniki badan czynnosci pluc u dzieci.

In 47 children after a 5 year remission of treated acute lymphoblastic leukemia respiratory function was assessed. In 11 a decrease of VC was found, while in 12 signs of obturation of lower airways were present. These results imply the presence of restrictive changes suggesting an interstitial lung disease. These children are at risk of developing a chronic pneumopathy.