[Agreal: its acceptibility. Review of the literature]. / Agréal: acceptabilité. Revue de la littérature.

The various studies of the tolerance of veralipride (Agreal) have revealed, in general, excellent results. A mild increase in the serum prolactin is always observed, but it is only very rarely accompanied by galactorrhoea and it is rapidly reversible. The clinical side effects are moderate and uncommon; they may consist of drowsiness, dryness of the mouth and occasionally nausea.

[Agreal: clinical experience. Review of the literature]. / Agréal: expérience clinique. Revue de la littérature.

A number of studies have been conducted to determine the effectiveness of veralipride (Agreal) in the treatment of the psycho-functional manifestations of menopause. All of these studies have obtained essentially similar results: very good effectiveness, in the order of 80 p. cent against hot flushes; very satisfactory effectiveness against the psycho-functional syndrome (50 to 70 p. cent). Headaches were the least affected by treatment (about 40 p. cent good results).

[Physiopathology of the menopause]. / Physiopathologie de la ménopause.

The menopause constitutes a considerable physiological alteration for the woman. The pre-menopausal period is essentially marked by luteal failure. The actual menopause, which coincides with the cessation of menstruation, corresponds to disturbance of the hypothalamo-hypophyseo-ovarian axis, of which the most dramatic manifestations are hot flushes and psychiatric disturbances. The post-menopausal period may be marked by peripheral and metabolic disorders.