RESUMO
The relative oral bioavailabilities of ciprofloxacin and ofloxacin when they were coadministered with water or an enteral feeding product (Ensure) were assessed in 13 healthy volunteers. The area under the concentration time curve from time zero to infinity and the maximum concentration of drug in serum for both drugs were reduced by Ensure in comparison with those by water (P < 0.01). However, Ensure reduced the percent relative bioavailability of ciprofloxacin (72% +/- 14%; range, 52 to 96%) significantly more than ofloxacin (90% +/- 8.3%; range, 74 to 105%) (P < 0.005). Coadministration of Ensure significantly diminished ciprofloxacin and ofloxacin absorption, but ciprofloxacin absorption was reduced significantly more than ofloxacin absorption.
Assuntos
Carboidratos/farmacologia , Ciprofloxacina/farmacocinética , Sacarose Alimentar , Nutrição Enteral , Ofloxacino/farmacocinética , Administração Oral , Adulto , Disponibilidade Biológica , Carboidratos/administração & dosagem , Ciprofloxacina/administração & dosagem , Estudos Cross-Over , Feminino , Alimentos Formulados , Humanos , Absorção Intestinal , Masculino , Ofloxacino/administração & dosagemAssuntos
Acetaminofen , Rotulagem de Medicamentos , Quinuclidinas , Humanos , Terminologia como AssuntoRESUMO
A new system for responding to Codes, or resuscitations of patients with cardiopulmonary arrest, was implemented at St Luke's Medical Center, Milwaukee. A teaching program was begun to establish the Advanced Cardiac Life Support (ACLS) guidelines as the standard of care. A task force defined the composition of the Code team and was then designated the Code Review Committee, meeting monthly to review all Codes. Indicators for review were established. Code review is followed by a letter to the physician Code team leader and/or registered nurse. Data for 18 months, still preliminary, show improved compliance with indicators for documentation and for adherence to ACLS guidelines.
