RESUMO
Management of parturients with a history of Fontan procedure requires careful monitoring of cardiovascular parameters and anticipation of potential complications. We describe potential pitfalls in a parturient with atriopulmonary Fontan circulation, who received epidural analgesia for labor and who later required emergency cesarean section. Low-dose local anesthetic in combination with meperidine provided excellent perioperative epidural analgesia and cardiovascular stability. Epidural analgesia during labor offered optimal pain relief and facilitated conversion to surgical anesthesia for an emergency cesarean section.
Assuntos
Analgesia Epidural/métodos , Anestesia Epidural/métodos , Anestesia Obstétrica/métodos , Cesárea/métodos , Tratamento de Emergência/métodos , Complicações Cardiovasculares na Gravidez , Adulto , Analgesia Epidural/instrumentação , Analgésicos Opioides/administração & dosagem , Anestesia Epidural/instrumentação , Anestesia Obstétrica/instrumentação , Cateteres de Demora , Feminino , Técnica de Fontan , Cardiopatias Congênitas/complicações , Cardiopatias Congênitas/cirurgia , Humanos , Meperidina/administração & dosagem , GravidezRESUMO
Acid extracts from rat pancreas and hypothalamus were analyzed for the presence of the antigenic determinant corresponding to the NH2 terminus of somatostatin-28 (SS28), using an antiserum directed against amino acids 1 to less than or equal to 11 of the SS28 molecule. On gel permeation chromatography the majority of the immunoreactive material from each tissue extract eluted in one zone compatible with a peptide of 1250 daltons. Purification of this immunoreactive material by reverse-phase HPLC and cation-exchange chromatography yielded two immunoreactive peptides from each tissue extract. The amino acid compositions of both peptides in pancreas and hypothalamus correspond to the fragment 1-12 of SS28. The more hydrophobic peptide from each tissue coeluted with synthetic SS28-(1-12) on HPLC, while the other one coeluted with synthetic SS28-(1-12)-amide. We conclude that the prosomatostatin fragment Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-OH is present in both rat hypothalamus and rat pancreas.
Assuntos
Hipotálamo/metabolismo , Pâncreas/metabolismo , Somatostatina/metabolismo , Sequência de Aminoácidos , Animais , Especificidade de Anticorpos , Fragmentos de Peptídeos/metabolismo , Ratos , Somatostatina/imunologia , Somatostatina-28RESUMO
Examination of 20 individuals without any pathological conditions of the cardiovascular system and 8 patients with myocardial hypertrophy has shown that the hypocalciemic hormone of the thyroid gland thyrocalcitonin has a certain negative inotropic effect and does not possess chrono- and dromotropic affects. The mechanism of the cardiac effect of thyrocalcitonin is evidently due to its effect on the metabolism of calcium and its transportation in the myocardial structures.
Assuntos
Calcitonina/uso terapêutico , Cardiomegalia/tratamento farmacológico , Coração/efeitos dos fármacos , Adulto , Idoso , Cardiomegalia/fisiopatologia , Ensaios Clínicos como Assunto , Relação Dose-Resposta a Droga , Avaliação de Medicamentos , Teste de Esforço , Feminino , Coração/fisiologia , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino , Pessoa de Meia-Idade , Contração Miocárdica/efeitos dos fármacos , Fatores de TempoAssuntos
Calcitonina/uso terapêutico , Osteoporose/tratamento farmacológico , Doença Crônica , Dermatomicoses/tratamento farmacológico , Dexametasona/efeitos adversos , Humanos , Pessoa de Meia-Idade , Osteoporose/induzido quimicamente , Pênfigo/tratamento farmacológico , Prednisolona/efeitos adversos , Triancinolona/efeitos adversosRESUMO
During early postnatal ontogenesis in the metaepiphyseal plate of the developing rat tibial bone, the borderline zone, the columnar cartilage zone and the zone of macrovesiculous cells differ in their cell composition, structure of basic substance and in functional and reactive potencies, which manifest themselves most distinctly after injection of growth-promoting hormones to the animals. The organic specificity of the metaepiphyseal borderline zone depends, first of all, on its intermediate position between the cartilage, fulfilling further bone growth lengthwise as an organ, and a developing endochondral bone substituting cartilage in the epiphysis. The borderline zone retains these features under hormonal effect. In the zone of columnar cells, it is reasonable to distinguish a layer of cuboidal cells--mature chondrocytes posessing great reactive and reparative possibilities, which become especially distincitive after prednisolon and TCT injection.