RESUMO
Invasive fusariosis in solid organ transplant is uncommon and usually presents as localized infection with favorable outcomes compared to hematologic malignancies or bone marrow transplants. We report the first case of Fusarium osteomyelitis in a patient following multi-visceral transplant and review Fusarium in organ transplant recipients and Fusarium bone and joint infections. Our case underscores the importance of early recognition and multidisciplinary approach to treatment and highlights potential failure to eradicate with amphotericin B monotherapy.
Assuntos
Anfotericina B/efeitos adversos , Fusariose/diagnóstico , Fusariose/microbiologia , Fusarium/isolamento & purificação , Osteomielite/microbiologia , Abdome/diagnóstico por imagem , Abdome/microbiologia , Anfotericina B/uso terapêutico , Antifúngicos/uso terapêutico , Transplante de Medula Óssea/efeitos adversos , Evolução Fatal , Fusariose/tratamento farmacológico , Fusarium/efeitos dos fármacos , Neoplasias Hematológicas , Humanos , Hospedeiro Imunocomprometido , Masculino , Pessoa de Meia-Idade , Osteomielite/tratamento farmacológico , Osteomielite/etiologia , Tomografia Computadorizada por Raios X , Transplantes/microbiologia , Voriconazol/uso terapêuticoRESUMO
Data describing the risk of lung transplantation (LT), clinical features, and outcomes of patients with cystic fibrosis (CF) infected with Burkholderia gladioli are limited. Herein, we report a case of disseminated B. gladioli infection characterized by bacteremia, necrotizing pneumonia, lung abscess, and empyema in a lung transplant recipient with CF, highlight the importance of accurate microbiological identification, and review published outcomes of LT in CF patients infected with B. gladioli, which include cases of pneumonia, tracheobronchitis, bacteremia, and abscesses, and demonstrate an all-cause 1-year mortality of approximately 23%, often after combined medical and surgical treatment.
