[Changes in the hemostasis system during long-term intravenous administration of nitroglycerin in the acute period of myocardial infarct]. / Izmeneniia sistemy gemostaza pri dlitel'nom vnutrivennom vvedenii nitroglitserina v ostrom periode infarkta miokarda.

Twenty seven patients were examined in the first hours of the onset of myocardial infarction for the hemostatic systems during a long-term intravenous administration of nitroglycerin (N). They were compared with 24 patients from a control group. N was found to reduce the signs of blood hypercoagulation, decrease platelet aggregation, increase fibrinolytic activity, and elevate antithrombin III levels. Hemostatic alterations were related to a hemodynamic response to nitroglycerin. Positive shifts in the hemostatic system were the most evident in the patients who exhibited higher cardiac output and lower signs of heart failure. In the patients without signs of heart failure, N deteriorated hemodynamic parameters, aggravated hypercoagulation and inhibited blood fibrinolytic activity.

[Effectiveness of combined use of kontrykal and nitroglycerin in the acute period of myocardial infarction]. / Effektivnost' kombinirovannogo primeneniia kontrikala i nitro- glitserina v ostrom periode infarkta miokarda.

The natural history and extension of myocardial infarction were studied from parameters of precordial ECG in 35 leads and central hemodynamic findings in 100 patients with acute myocardial infarction. The least extension of myocardial lesion areas and better central hemodynamic parameters and a sharp reduction in the frequency of complications and hospital mortality in patients receiving a combined therapy with contrykal and nitroglycerin as a continuous long-term infusion within the first 24 hours of myocardial infarction as compared with the controls and in those having these agents alone.