Assuntos
Antineoplásicos/efeitos adversos , Comportamento de Doença , Neoplasias/terapia , Educação de Pacientes como Assunto/tendências , Adulto , Idoso , Antineoplásicos/uso terapêutico , Neoplasias da Mama/psicologia , Neoplasias da Mama/terapia , Carcinoma Ductal de Mama/psicologia , Carcinoma Ductal de Mama/terapia , Quimioterapia Adjuvante/efeitos adversos , Quimioterapia Adjuvante/psicologia , Terapia Combinada/efeitos adversos , Terapia Combinada/psicologia , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/prevenção & controle , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/psicologia , Feminino , Alemanha , Humanos , Neoplasias Pulmonares/psicologia , Neoplasias Pulmonares/terapia , Linfoma Difuso de Grandes Células B/psicologia , Linfoma Difuso de Grandes Células B/terapia , Masculino , Terapia Neoadjuvante/efeitos adversos , Terapia Neoadjuvante/psicologia , Neoplasias/psicologiaAssuntos
Infecções por Papillomavirus/diagnóstico , Lesões Pré-Cancerosas/diagnóstico , Neoplasias Cutâneas/diagnóstico , Adulto , Neoplasias do Ânus/diagnóstico , Criança , Condiloma Acuminado/diagnóstico , Feminino , Humanos , Masculino , Neoplasias Otorrinolaringológicas/diagnóstico , Neoplasias do Colo do Útero/diagnósticoRESUMO
OBJECTIVE: To describe a cytomorphologic criterion that may help improve diagnostic safety in morphologic differentiation of non-Hodgkin's lymphoma (NHL) from carcinoma or sarcoma and investigate the significance of this cytomorphologic phenomenon. STUDY DESIGN: Eighty-two smears of NHL, carcinoma and sarcoma smears were examined. Forty-five smears were from patients with carcinoma and 35 from patients with NHL. The remaining 2 smears were from patients with sarcoma. RESULTS: In 40 of 46 smears of carcinoma or sarcoma the nuclear membrane was assessed as "open" by the observer. In 6 smears the membrane was assessed as "closed. " In 30 of 35 smears with histologically confirmed NHL, the membrane was estimated as being closed. In the remaining 5 smears it was assessed as open. The sensitivity of evaluating the parameter as open or closed membrane was 87% and the specificity was 86%. The negative predictive value was 89%, and the positive predictive value was 83%. CONCLUSION: We suggest that the presence of an open or closed nuclear membrane may be helpful in differentiation of malignant lymphoma from carcinoma or sarcoma and may help improve diagnostic safety in daily practice.
Assuntos
Carcinoma/diagnóstico , Linfoma não Hodgkin/diagnóstico , Membrana Nuclear/ultraestrutura , Sarcoma/diagnóstico , Carcinoma/ultraestrutura , Diagnóstico Diferencial , Humanos , Linfoma não Hodgkin/ultraestrutura , Sarcoma/ultraestruturaRESUMO
OBJECTIVE: To determine the usefulness of fine needle aspiration cytology (FNAC) in combination with flow cytometry on the new World Health Organization (WHO) classification of malignant lymphoma. STUDY DESIGN: Smears and flow cytometry reports of patients who underwent both methods at the same time were independently examined. Both methods were classified according to the new WHO classification of malignant lymphoma. RESULTS: A group of 131 smears were examined. In 89 cases exact diagnosis was made by cytomorphology. Twenty-five cases were not classified exactly or were classified incorrectly, resulting in a sensitivity of 96.4% and a specificity of 85%. With flow cytometry, only 30 of 131 patients could be classified exactly, resulting in a sensitivity of 27% and specificity of 100%, respectively. The combination of methods showed a sensitivity of 85% and specificity of 100%. CONCLUSION: The combination of FNAC and flow cytometry obtained by FNAC can distinguish between benign and malignant lymphoid infiltrates and support a diagnosis of lymphoma.
