RESUMO
The automated system for measuring canine paw pressure is a very useful tool for the evaluation of nonsteroid antiinflammatory drugs such as indomethacin and ibuprofen in the dog synovitis model. The apparatus has been designed to give the operator control over the dog's posture while measuring hind-paw pressure. The stability of the measuring platform permits reproducible measurement of paw pressures. The software package performs direct data recording and data reduction and eliminates tedious manual calculations. Subsequently, the software produces a printout summarizing the experimental results in tabular and graphic form.
Assuntos
Anti-Inflamatórios/farmacologia , Pé/fisiopatologia , Sinovite/fisiopatologia , Animais , Modelos Animais de Doenças , Cães , Feminino , Pé/fisiologia , Ibuprofeno/farmacologia , Indometacina/farmacologia , Masculino , Microcomputadores , Pressão , Software , Fatores de TempoRESUMO
The mass spectra of 75 analogs of trimethoprim were used in a study correlating mass spectrometric data with biological activity. Using pattern recognition techniques a correlation was obtained. Experiments to elaborate the basis of the correlation are described.
