Intensive interferon therapy does not increase virological response rates in African Americans with chronic hepatitis C.

To determine if an intensive regimen of daily, high-dose interferon would improve the initial response rates to therapy for hepatitis C genotype 1 among African American and Caucasian patients, we conducted a retrospective analysis of a treatment trial conducted between October 1995 and June 1997. Patients were randomized to 24 weeks of therapy with interferon--alpha-2b at either 5 MU daily or 3 MU three times a week. On the standard interferon regimen (3 MU three times a week) African Americans and Caucasians had similar initial response rates. However, unlike Caucasians, African Americans did not have an increased initial virological response when treated with an intensive, daily dose regimen. Levels of HCV RNA decreased more slowly during the first 12 weeks of therapy among African Americans. Nelson-Aalen cumulative hazard estimates for the different race and dose combinations revealed that Caucasians who received daily interferon were most likely to have an initial response (logrank, P < 0.001).

Temporal trends over ten years in formal inpatient gastroenterology consultations at an inner city hospital.

GOALS: Inpatient consultation is an important, but poorly understood, component of medical subspecialty practices. In a time when all services strive for cost-effective and efficient treatments, little is known about the epidemiology of inpatient subspecialty consultation. This study is designed to describe the nature and trends of formal inpatient gastroenterology consultations during the past decade. STUDY: All inpatient gastroenterology consultations at Grady Memorial Hospital in Atlanta, GA, in 1998 and 1988 were retrospectively reviewed. Percentages of inpatient gastroenterology consultations were calculated for each year accordingly. Top ten reasons for inpatient gastroenterology consultations were compared. RESULTS: Formal inpatient gastroenterology consultations have steadily increased in the past 10 years (2.8% of all admissions in 1988 to 4.8% in 1998, < 0.0001). Inpatient gastrointestinal endoscopic procedures have significantly increased over the past decade (30.9% of the total consultations in 1988 to 36.1% in 1998, = 0.008). The leading reasons for formal inpatient gastroenterology consultations in 1998 were hematemesis, abnormal liver tests, hematochezia, anemia, and melena. Consultations for abnormal liver tests have significantly decreased in the past 10 years (27% of the total consultations in 1988 to 16% in 1998, < 0.001). CONCLUSIONS: Formal inpatient gastroenterology consultations and inpatient gastrointestinal endoscopic procedures have significantly increased over the past 10 years, despite pressures to decrease costs of inpatient care. The main reason for formal inpatient gastroenterology consultations shifted from abnormal liver tests to gastrointestinal bleeding.