[Methods of treatment of acute hepatic insufficiency with isolated hepatocytes]. / Sposoby primeneniia izolirovannykh gepatotsitov dlia lecheniia ostroi pechenochnoi nedostatochnosti.

The paper describes different methods for using isolated hepatocytes to compensate hepatic dysfunctions and to treat hepatic failure. Most of them are safe and produce no complications if isolated hepatocytes are separated from blood with the semipermeable membrane. The survival and functional activity of isolated hepatocytes transplanted into different places and organs are ambiguous and unequal in terms of efficiency. Search for a rational and optimal method for implantation of isolated hepatocytes, for conditions for their functioning, for combinations of different cells, for proliferation of the implanted cells is a subject of special interest and it is in progress. Many procedures have been experimentally justified and are being now used clinically to treat hepatic failure in various hepatic diseases.

[Allogeneic hepatic cell suspension in the treatment of liver insufficiency]. / Allogennaia kletochnaia vzves' pecheni pri lechenii pechenochnoi nedostatochnosti.

A study was made of a possibility of using isolated hepatocytes for the treatment of diseases of the liver in animals. The optimal dose of the cell suspension in intravascular, intraperitoneal, intrapleural and subcutaneous administration was determined; a reaction of the experimental animals to this biological substrate was studied. The efficacy of the isolated hepatocytes in the treatment of hepatic insufficiency is demonstrated; also a comparative assessment of the mentioned methods of the cell suspension administration is given.