RESUMO
The content of CD117(+)cells in the kidneys and CD45(low)CD117(+)cells in the bone marrow and blood of mice were studied after partial nephrectomy and under conditions of macrophage stimulation with 3-aminophthalhydrazide. The counts of tubular CD117(+)epitheliocytes sharply increased and the content of CD45(low)CD117(+)cells in the bone marrow decreased after renal damage. Injection of 3-aminophthalhydrazide stimulated the expression of CD117 by renal epitheliocytes and led to reduction of CD45(low)CD117(+)cell counts in the bone marrow and blood. Macrophages stimulated proliferative processes in the kidney and differentiation of stem cells in the bone marrow due to synergic effects of their cytokines and stem cell factor.
Assuntos
Rim/efeitos dos fármacos , Rim/metabolismo , Luminol/análogos & derivados , Proteínas Proto-Oncogênicas c-kit/metabolismo , Animais , Imuno-Histoquímica , Antígenos Comuns de Leucócito/metabolismo , Luminol/farmacologia , Macrófagos/efeitos dos fármacos , Macrófagos/metabolismo , CamundongosRESUMO
The effects of 3-aminophthalhydrazide and carrageenan on reparative regeneration and expression of CD117 by liver cells after partial hepatectomy were studied in mice. 3-Aminophthalhydrazide stimulated regeneration of the liver and increased the count of CD117(+) hepatocytes. By contrast, carrageenan inhibited liver reparation and CD117 expression.
Assuntos
Hepatectomia , Regeneração Hepática/fisiologia , Fígado/metabolismo , Proteínas Proto-Oncogênicas c-kit/metabolismo , Animais , Carragenina/farmacologia , Contagem de Células , Imuno-Histoquímica , Antígeno Ki-67/metabolismo , Regeneração Hepática/efeitos dos fármacos , Substâncias Luminescentes/farmacologia , Luminol/análogos & derivados , Luminol/farmacologia , Camundongos , Estatísticas não ParamétricasRESUMO
Influence of spatially distributed field of electric impulses in a projection to cervical ganglions of the sympathetic nervous system on angiogenesis in ischemic muscular tissue of a rat's shin has been studied. It is revealed that blood supply of animals, influenced by the field, is restored through increase in quantity of capillaries in ischemic tissues, and number of products of endogenous intoxication is reduced.
