Effects of orally administered Thymus vulgaris leaves on memory, anxiety, depression, and sleep quality in university students: a randomized controlled trial.

OBJECTIVE: The aim of this study was to evaluate the effects of orally administering Thymus vulgaris leaves on memory performance, anxiety, depression, and sleep quality in a sample of university students. PATIENTS AND METHODS: This randomized controlled trial included 106 students who were randomly assigned to one of two groups. The first group received 500 mg of Thymus vulgaris leaves twice daily, while the second group received a placebo. The intervention period lasted for one month. The participants' memory performance (both prospective and retrospective), levels of anxiety and depression, and sleep quality were assessed using the Prospective and Retrospective Memory Questionnaire (PRMQ), Hospital Anxiety and Depression Scale (HADS), and Pittsburgh Sleep Quality Inventory (PSQI) at the beginning of the study and after one month. RESULTS: The findings revealed significant reductions in the scores of all scales and subscales, with the exception of the sleep latency and sleep duration components of the Pittsburgh Sleep Quality Inventory, among the group that received Thymus vulgaris leaves in comparison to the control group. CONCLUSIONS: Thymus vulgaris leaves, a traditional food source, demonstrate potential for enhancing both prospective and retrospective memory, alleviating anxiety and depression, and improving sleep quality in university students.

Exploring the therapeutic potential of fisetin: a comprehensive study on its anti-nociceptive and anti-inflammatory effects.

OBJECTIVE: This study's primary objective was to explore and validate the pain-relieving and inflammation-reducing properties of fisetin, a flavonoid known for its antioxidant benefits, using different mouse models. MATERIALS AND METHODS: We assessed fisetin's pain-relieving effects using mouse models exposed to both heat-induced and chemical-induced pain. The inflammation-reducing capacity of fisetin was evaluated using the carrageenan-triggered paw swelling test, focusing on the influx of leukocytes in the peritoneal space. The air pouch test was utilized to determine fisetin's ability to counteract proinflammatory cytokines. The performance of fisetin, when paired with opioid blockers, was analyzed, and juxtaposed with results from conventional medicines. The muscle-relaxing potential of fisetin was assessed through the open field assessment. RESULTS: Fisetin consistently demonstrated marked anti-inflammatory actions across various models. It also proved to be effective in reducing pain in the pain-induced models. When combined with opioid blockers, fisetin's effects were on par with those of traditional medications. Noteworthily, fisetin displayed muscle-relaxing properties in the open-field assessment. CONCLUSIONS: The compiled data showcases fisetin as a powerful anti-inflammatory agent with significant pain-relieving capacities, positioning it as a promising contender for pain treatment modalities.